CGDpheno3: Multi-system survey of mouse physiology in 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross (2012)

Lenarcic AB, Svenson KL, Churchill GA, Valdar W. A general Bayesian approach to analyzing diallel crosses of inbred strains. Genetics. 2012 Feb;190(2):413-35.   PubMed 22345610     FullText


       
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Institutional authorship Center for Genome Dynamics (CGD).
Participants Svenson KL, Lenarcic AB, Churchill GA, Valdar W
ContactKaren L Svenson     karen.svenson@jax.org     Lab web site
AffiliationCenter for Genome Dynamics (CGD)
AcknowledgementsPartial support from the National Institutes of Health (NIH) Center of Excellence in Genome Sciences grants P50 MH090338 and P50 MH006582, from NIH grant GM076468, from The Jackson Laboratory, and from the University of North Carolina Lineberger Comprehensive Cancer Center.
Project type Phenotype strain survey data set
MPD identifiersCGDpheno3     MPD:439
Data changelog No updates/corrections.       Initial release date: 12/2012.
Formatted citation
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An assessment of F1 hybrids bred from the 8 CC founder strains. Data for the founder strains are also present.

Summary of procedures that were conducted
• metabolic panel Glucose (plasma). 4h fast.
• lipid profile Cholesterol, HDL, triglycerides. 4h fast, plasma.
• complete blood count Hematology.
• tail cuff Heart rate and blood pressure. Conscious mice.
• ECG Wave amplitudes and intervals. Conscious.
• DXA Body mass, fat mass, lean mass, bone mineral density and content, bone area.
• body weight
Mice: CC diallel   62 strains including progenitors   ♀♂   age 8-16wks   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    CGDpheno3 43901 metabolic panel (none) glucose (plasma GLU, 4h fast)   [mg/dL]  GLU CC diallel w/CC8 62 both 8wks N=5
    CGDpheno3 43902 lipid profile (none) total cholesterol (plasma CHOL)   [mg/dL]  CHOL CC diallel w/CC8 62 both 8wks N=5
    CGDpheno3 43903 lipid profile (none) HDL cholesterol (plasma HDL)   [mg/dL]  HDL CC diallel w/CC8 62 both 8wks N=5
    CGDpheno3 43904 lipid profile (none) triglycerides (plasma TG, 4h fast)   [mg/dL]  TG CC diallel w/CC8 62 both 8wks N=5
    CGDpheno3 43905 complete blood count (none) red blood cell count (RBC; per volume x 106)   [n/µL]  RBC CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43906 complete blood count (none) white blood cell count (WBC; per volume x 103)   [n/µL]  WBC CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43907 complete blood count (none) lymphocyte differential (percent of total WBC)   [%]  pctLYMP CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43908 complete blood count (none) neutrophil differential (percent of total WBC)   [%]  pctNEUT CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43909 complete blood count (none) monocyte differential (percent of total WBC)   [%]  pctMONO CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43910 complete blood count (none) basophil differential (percent of total WBC)   [%]  pctBASO CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43911 complete blood count (none) eosinophil differential (percent of total WBC)   [%]  pctEOS CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43912 complete blood count (none) large unstained cells (percent of total WBC)   [%]  pctLUC CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43913 complete blood count (none) reticulocyte differential (percent of total RBC)   [%]  pctRetic CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43914 complete blood count (none) RBC corpuscular distribution width (RDW)   [%]  RDW CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43915 complete blood count (none) mean RBC corpuscular volume (MCV)   [fL]  MCV CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43916 complete blood count (none) mean RBC corpuscular hemoglobin conent (MCH)   [pg]  MCH CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43917 complete blood count (none) mean RBC corpuscular hemoglobin concentration (MCHC)   [g/dL]  MCHC CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43918 complete blood count (none) RBC corpuscular hemoglobin concentration mean (CHCM)   [g/dL]  CHCM CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43919 complete blood count (none) hemoglobin concentration distribution width (HDW)   [g/dL]  HDW CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43920 complete blood count (none) measured hemoglobin (HGB)   [g/dL]  mHGB CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43921 complete blood count (none) calculated hemoglobin (HGB)   [g/dL]  cHGB CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43922 complete blood count (none) hematocrit (HCT)   [%]  HCT CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43923 complete blood count (none) platelet count (PLT; units per volume x 103)   [n/µL]  PLT CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43924 complete blood count (none) mean platelet volume (MPV)   [fL]  MPV CC diallel w/CC8 62 both 7wks N=5
    CGDpheno3 43925 tail cuff (none) systolic blood pressure   [mmHg]  systolic_BP CC diallel w/par 24 both 10wks N=4
    CGDpheno3 43926 tail cuff (none) pulse rate   [n/min]  pulse CC diallel w/par 24 both 10wks N=4
    CGDpheno3 43927 ECG (none) heart rate   [n/min]  HR CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43928 ECG (none) coefficient of variance (heart rate)   [%]  CV CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43929 ECG (none) R-wave amplitude   [mV]  R_amplitude CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43930 ECG (none) R plus S-wave amplitude   [mV]  RS_amplitude CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43931 ECG (none) interval between R-waves (RR)   [ms]  RR CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43932 ECG (none) interval between peak of P-wave to Q-wave (PQ)   [ms]  PQ CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43933 ECG (none) interval between peak of P-wave to R-wave (PR)   [ms]  PR CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43934 ECG (none) interval between beginning and end of QRS complex   [ms]  QRS CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43935 ECG (none) interval between peak of Q-wave to end of T-wave (QT)   [ms]  QT CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43936 ECG (none) rate-corrected QT interval   [ms]  QTc CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43937 ECG (none) difference between smallest and largest QT interval   [ms]  QT_dispersion CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43938 ECG (none) difference between smallest and largest rate-corrected QT interval   [ms]  QTc_dispersion CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43939 ECG (none) interval between S-wave and end of T-wave (ST)   [ms]  ST CC diallel w/par 42 both 12wks N=5
    CGDpheno3 43940 DXA (none) whole body bone mineral density (BMD)   [g/cm2]  BMD CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43941 DXA (none) whole body bone mineral content (BMC)   [g]  BMC CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43942 DXA (none) whole body bone area, head excluded   [cm2]  bone_area CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43943 DXA (none) total body area without head   [cm2]  total_area CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43944 DXA (none) weight of lean tissue mass, head excluded   [g]  LTM CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43945 DXA (none) percent fat, head excluded   [%]  pct_fat CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43946 DXA (none) total tissue mass, head excluded   [g]  TTM CC diallel w/CC8 61 both 16wks N=5
    CGDpheno3 43947 body weight (none) body weight   [g]  bw CC diallel w/CC8 61 both 16wks N=5
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