Brown1: Anxiety, exploratory behavior, and motor activity in 14 inbred strains of mice (2004)

O'Leary TP, Gunn RK, Brown RE. What are we measuring when we test strain differences in anxiety in mice? Behav Genet. 2013 Jan;43(1):34-50. doi: 10.1007/s10519-012-9572-8. Epub 2013 Jan 4.   PubMed 23288504  


       
Brown1 downloads
• Download Brown1 project data set     one row per animal, one column per trait
• Download Brown1 strain means, SD, N, etc.     one row per strain/sex/measure
• Brown1 supplementary data
Participants Richard E Brown       Dalhousie University Halifax, Nova Scotia CANADA
Rhian K Gunn       Dalhousie University Halifax, Nova Scotia CANADA
Heather M Schellinck       Dalhousie University Halifax, Nova Scotia CANADA
Aimee A Wong       Dalhousie University Halifax, Nova Scotia CANADA
Timothy P O'Leary       Dalhousie University Halifax, Nova Scotia CANADA
ContactRichard E Brown     rebrown@dal.ca     Lab web site
AcknowledgementsFunding provided by Natural Sciences and Engineering Research Council of Canada (NSERC 7441)

Generous funds from AstraZeneca R&D Boston were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersBrown1     MPD:94
Data changelog No updates/corrections.       Initial release date: 02/2008.
Formatted citation
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A set of definitions is available.

Summary of procedures that were conducted
• body weight
• elevated plus maze Locomotor, exploratory, and anxiety-related behavior.
• elevated zero maze Locomotor, exploratory, and anxiety-related behavior.
• light-dark box Anxiety, avoidance behavior.
• open field test Locomotor, exploratory, and anxiety-related behavior.
Mice: inbred   14 strains   ♀♂   age 10wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Brown1 9401 open field test (none) total locomotor activity (line crosses plus rearing, dur=5min), day 1   [n]  activity_d1_OFT inbred 14 both 10wks N=12
    Brown1 9402 light-dark box (none) total activity (line crosses plus rearing, dur=5min)   [n]  activity_LD inbred 14 both 10wks N=13
    Brown1 9403 elevated plus maze (none) total activity (line crosses plus rearing, dur=5min)   [n]  activity_EPM inbred 14 both 10wks N=12
    Brown1 9404 elevated zero maze (none) total activity (line crosses plus rearing, dur=5min)   [n]  activity_EZM inbred 13 both 10wks N=9
    Brown1 9410 open field test (none) fecal boli count (dur=5min), day 1   [n]  defecation_d1_OFT inbred 14 both 10wks N=13
    Brown1 9411 open field test (none) freezing duration, day 1   [s]  freeze_d1_OFT inbred 14 both 10wks N=13
    Brown1 9412 open field test (none) grooming duration, day 1   [s]  groom_d1_OFT inbred 14 both 10wks N=13
    Brown1 9413 open field test (none) total stretch attends (dur=5min), day 1   [n]  stretch_d1_OFT inbred 14 both 10wks N=13
    Brown1 9414 open field test (none) urine puddle count (dur=5min), day 1   [n]  urination_d1_OFT inbred 14 both 10wks N=13
    Brown1 9415 light-dark box (none) dark zone duration   [s]  dark_dur_LD inbred 14 both 10wks N=13
    Brown1 9416 light-dark box (none) fecal boli count   [n]  defecation_LD inbred 14 both 10wks N=13
    Brown1 9417 light-dark box (none) grooming duration   [s]  groom_LD inbred 14 both 10wks N=13
    Brown1 9418 light-dark box (none) total stretch attends   [n]  stretch_LD inbred 14 both 10wks N=13
    Brown1 9419 light-dark box (none) urine puddle count   [n]  urination_LD inbred 14 both 10wks N=13
    Brown1 9420 elevated plus maze (none) open arms avoidance index   [n]  avoid_index_EPM inbred 14 both 10wks N=12
    Brown1 9421 elevated plus maze (none) closed arms duration   [s]  close_dur_EPM inbred 14 both 10wks N=12
    Brown1 9422 elevated plus maze (none) closed arms entries   [n]  close_ent_EPM inbred 14 both 10wks N=12
    Brown1 9423 elevated plus maze (none) closed arms, proportion of total time   [ratio]  close_prop_EPM inbred 14 both 10wks N=12
    Brown1 9424 elevated plus maze (none) fecal boli count   [n]  defecation_EPM inbred 14 both 10wks N=13
    Brown1 9425 elevated plus maze (none) grooming duration   [s]  groom_EPM inbred 14 both 10wks N=13
    Brown1 9426 elevated plus maze (none) total head-dips   [n]  headip_EPM inbred 14 both 10wks N=13
    Brown1 9427 elevated plus maze (none) total stretch attends   [n]  stretch_EPM inbred 14 both 10wks N=13
    Brown1 9428 elevated plus maze (none) urine puddle count   [n]  urination_EPM inbred 14 both 10wks N=13
    Brown1 9429 elevated zero maze (none) closed zone duration   [s]  close_dur_EZM inbred 13 both 10wks N=9
    Brown1 9430 elevated zero maze (none) closed zone entries   [n]  close_ent_EZM inbred 13 both 10wks N=9
    Brown1 9431 elevated zero maze (none) closed zone, proportion of total time   [ratio]  close_prop_EZM inbred 13 both 10wks N=9
    Brown1 9432 elevated zero maze (none) fecal boli count   [n]  defecation_EZM inbred 13 both 10wks N=9
    Brown1 9433 elevated zero maze (none) grooming duration   [s]  groom_EZM inbred 13 both 10wks N=9
    Brown1 9434 elevated zero maze (none) total head-dips   [n]  headip_EZM inbred 13 both 10wks N=9
    Brown1 9435 elevated zero maze (none) total stretch attends   [n]  stretch_EZM inbred 13 both 10wks N=9
    Brown1 9436 elevated zero maze (none) urine puddle count   [n]  urination_EZM inbred 13 both 10wks N=9
    Brown1 9450 open field test (none) total time in center square (dur=5min), day 1   [s]  center_dur_d1_OFT inbred 14 both 10wks N=13
    Brown1 9451 open field test (none) total center square entries (dur=5min), day 1   [n]  center_ent_d1_OFT inbred 14 both 10wks N=13
    Brown1 9452 light-dark box (none) light zone duration   [s]  light_dur_LD inbred 14 both 10wks N=13
    Brown1 9453 light-dark box (none) light zone, proportion of total time   [ratio]  light_prop_LD inbred 14 both 10wks N=13
    Brown1 9454 light-dark box (none) transitions between light and dark zones   [n]  trans_LD inbred 14 both 10wks N=13
    Brown1 9455 elevated plus maze (none) open arms duration   [s]  open_dur_EPM inbred 14 both 10wks N=12
    Brown1 9456 elevated plus maze (none) total open arms entries   [n]  open_ent_EPM inbred 14 both 10wks N=12
    Brown1 9457 elevated plus maze (none) open arms, percent of total entries   [%]  open_ent_prop_EPM inbred 14 both 10wks N=12
    Brown1 9458 elevated plus maze (none) open arms, proportion of total time   [ratio]  open_prop_EPM inbred 14 both 10wks N=12
    Brown1 9459 elevated zero maze (none) open zone duration   [s]  open_dur_EZM inbred 13 both 10wks N=9
    Brown1 9460 elevated zero maze (none) open zone entries   [n]  open_ent_EZM inbred 13 both 10wks N=9
    Brown1 9461 elevated zero maze (none) open zone, proportion of total time   [ratio]  open_prop_EZM inbred 13 both 10wks N=9
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