ITP survival analysis:   (R/S)-1,3-butanediol

Intervention:   (R/S)-1,3-butanediol     ketogenic dietary supplement, anti-aging
Trial code: BD Dose: 100,000 ppm initiated at age: 6 mo Sex: both Cohort: C2017
This compound had a significant effect on survival:   females p = 0.0395

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – female
BD effect on survival, females, test site = All
Log-rank test chisq = 4.2412 p = 0.0395
Wang-Allison test odds ratio = 1.7322 p = 0.1208
Quantiles BD Control % difference
25% died before day: 768 767 0 %
Median lifespan (days) 881 868 +1 %
75% died before day: 1006 958 +5 %
90% died before day: 1101 1060 +4 %
Max lifespan observed (days) 1272 1221
Number of mice at start 134 276
Animal censor events are denoted by + marks in the plot
All test sites combined – male
BD effect on survival, males, test site = All
Log-rank test chisq = 2.558 p = 0.1097
Wang-Allison test odds ratio = 1.4107 p = 0.314
Quantiles BD Control % difference
25% died before day: 605 447 +35 %
Median lifespan (days) 785 718 +9 %
75% died before day: 901 919 -2 %
90% died before day: 1066 1029 +4 %
Max lifespan observed (days) 1353 1258
Number of mice at start 145 285
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – female
TJL – female      
BD effect on survival, females, test site = TJL
Log-rank test chisq = 4.2387 p = 0.0395
Wang-Allison test odds ratio = 1.8693 p = 0.2594
Quantiles BD Control % difference
25% died before day: 842 760 +11 %
Median lifespan (days) 928 870 +7 %
75% died before day: 1043 968 +8 %
90% died before day: 1101 1068 +3 %
Max lifespan observed (days) 1252 1209
Number of mice at start 48 96
Animal censor events are denoted by + marks in the plot
TJL – male
TJL – male      
BD effect on survival, males, test site = TJL
Log-rank test chisq = 0.0345 p = 0.8526
Wang-Allison test odds ratio = 1.1489 p = 0.7876
Quantiles BD Control % difference
25% died before day: 561 488 +15 %
Median lifespan (days) 764 748 +2 %
75% died before day: 870 949 -8 %
90% died before day: 1083 1079 0 %
Max lifespan observed (days) 1353 1226
Number of mice at start 54 102
Animal censor events are denoted by + marks in the plot
UM – female
UM – female      
BD effect on survival, females, test site = UM
Log-rank test chisq = 0.6384 p = 0.4243
Wang-Allison test odds ratio = 1.1827 p = 0.7693
Quantiles BD Control % difference
25% died before day: 702 820 -14 %
Median lifespan (days) 826 902 -8 %
75% died before day: 963 1000 -4 %
90% died before day: 1101 1098 0 %
Max lifespan observed (days) 1272 1221
Number of mice at start 43 90
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
BD effect on survival, males, test site = UM
Log-rank test chisq = 0.0084 p = 0.9271
Wang-Allison test odds ratio = 0.9245 p = 1.0
Quantiles BD Control % difference
25% died before day: 576 468 +23 %
Median lifespan (days) 753 790 -5 %
75% died before day: 883 933 -5 %
90% died before day: 985 1019 -3 %
Max lifespan observed (days) 1336 1233
Number of mice at start 42 88
Animal censor events are denoted by + marks in the plot
UT – female
UT – female      
BD effect on survival, females, test site = UT
Log-rank test chisq = 4.5634 p = 0.0327
Wang-Allison test odds ratio = 2.2897 p = 0.1442
Quantiles BD Control % difference
25% died before day: 762 696 +9 %
Median lifespan (days) 864 824 +5 %
75% died before day: 965 937 +3 %
90% died before day: 1129 993 +14 %
Max lifespan observed (days) 1237 1198
Number of mice at start 43 90
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
BD effect on survival, males, test site = UT
Log-rank test chisq = 6.5581 p = 0.0104
Wang-Allison test odds ratio = 2.4364 p = 0.1473
Quantiles BD Control % difference
25% died before day: 699 400 +75 %
Median lifespan (days) 810 676 +20 %
75% died before day: 912 825 +11 %
90% died before day: 1066 963 +11 %
Max lifespan observed (days) 1197 1258
Number of mice at start 49 95
Animal censor events are denoted by + marks in the plot


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Statistical definitions