Studies of activity, behavior, and forebrain morphometry in two laboratories. Purpose: To investigate the stability of behaviors, such as activity, anxiety, exploratory behavior, motor and spatial learning, and evaluate replicability of brain morphometric measurements, such as brain weights, corpus collosum, hippocampus and anterior commisures sizes, across inbred strains of mice in two laboratories (Portland, Oregon USA and Edmonton, Alberta CANADA).

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains behavior — activity and motor function &ndash elevated plus maze   Wahlsten1 distance traveled [cm]           during minute: • 1  • 2  • 3  • 4  • 5    time comparison   21 strains   age 9wks Wahlsten1 movement         • % time moving        • speed when moving        21 strains   age 9wks   behavior — activity and motor function &ndash open field test   Wahlsten1 distance traveled [cm]           during minute: • 1  • 2  • 3  • 4  • 5    time comparison   21 strains   age 9wks Wahlsten1 average speed over 5 min trial   [cm/sec] 21 strains   age 9wks   behavior — anxiety &ndash elevated plus maze   Wahlsten1 time spent in two closed arms   [s] 21 strains   age 9wks Wahlsten1 number fecal boli, 5 min trial   [n] 21 strains   age 9wks Wahlsten1 percent time spent in open arms vs closed   [%] 21 strains   age 9wks   behavior — anxiety &ndash open field test   Wahlsten1 percent of 5 min spent within 10 cm of wall   [%] 21 strains   age 9wks Wahlsten1 number of fecal boli, within 5 min trial   [n] 21 strains   age 9wks   behavior — exploratory &ndash elevated plus maze   Wahlsten1 exploratory         • avg distance traveled in 1min        time spent in:             • center hub              • two open arms              21 strains   age 9wks   behavior — exploratory &ndash open field test   Wahlsten1 average distance traveled in 1 min   [cm] 21 strains   age 9wks   brain — morphology   Wahlsten1 brain weight (after fixation and trimming)         • weight        • normalized weight        21 strains   age 12.5wks Wahlsten1 corpus collosum         • length at mid-sagittal plane        • cross-sectional area at midplane        • index (0=absent 1=present)        21 strains   age 12wks Wahlsten1 hippocampus         • length at mid-sagittal plane        • cross-sectional area at midplane        • index (0=absent 1=present)        21 strains   age 12wks Wahlsten1 anterior commissure         • length at mid-sagittal plane        • cross-sectional area at midplane        • index (0=absent 1=present)        21 strains   age 12wks   local experiment parameter   Wahlsten1 body weight, end of testing   [g] 21 strains   age 12.5wks Wahlsten1 tissue quality; 0=no faults, 1=one or more faults   [score] 21 strains   age 12wks Display strain means in the above table for: select a strain 129S1/SvImJ A/J AKR/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J C57L/J C58/J CAST/EiJ DBA/2J FVB/NJ MOLF/EiJ NOD/ShiLtJ NZB/BlNJ PERA/EiJ PL/J SJL/J SM/J SPRET/EiJ SWR/J   Compare two strains: select strain 1 129S1/SvImJ A/J AKR/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J C57L/J C58/J CAST/EiJ DBA/2J FVB/NJ MOLF/EiJ NOD/ShiLtJ NZB/BlNJ PERA/EiJ PL/J SJL/J SM/J SPRET/EiJ SWR/J vs. select strain 2 129S1/SvImJ A/J AKR/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J C57L/J C58/J CAST/EiJ DBA/2J FVB/NJ MOLF/EiJ NOD/ShiLtJ NZB/BlNJ PERA/EiJ PL/J SJL/J SM/J SPRET/EiJ SWR/J   Compare female vs. male for: select a strain 129S1/SvImJ A/J AKR/J BALB/cByJ BTBR T+ tf/J C3H/HeJ C57BL/6J C57L/J C58/J CAST/EiJ DBA/2J FVB/NJ MOLF/EiJ NOD/ShiLtJ NZB/BlNJ PERA/EiJ PL/J SJL/J SM/J SPRET/EiJ SWR/J   Display overall measurement averages (all strains combined) in the above table

Notes

Wahlsten D, Bachmanov A, Finn DA, Crabbe JC. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16364-9. Epub 2006 Oct 19.     PubMed    MGI Wahlsten D, Metten P, Crabbe JC. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res. 2003 May 2;971(1):47-54.     PubMed    MGI There have been no updates or corrections to the dataset since it was first released in Jul, 2003 This study was conducted on the same set of mice rated for wildness and ease of handling (Wahlsten2). Wahlsten1 data were measured at two different laboratories. The data were pooled to produce the above MPD measurements. More on comparability of results from the two laboratories. Please note. Some strain means have N < 3 animals (click for table). Some measurements were derived by MPD staff, based on supplied data (click for list).

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The Wahlsten1 project data set. Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file Wahlsten1 individual animal data in list format. Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file Wahlsten1 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Wahlsten1 protocol document HTML Wahlsten1 animal documentation HTML Supplemental data None