Schughart5: Susceptibility to influenza A (H3N2) viral infection: body weight and lung weight in females of the 8 inbred founder strains of the Collaborative Cross (2016)

Leist SR, Pilzner C, van den Brand JM, Dengler L, Geffers R, Kuiken T, Balling R, Kollmus H, Schughart K. Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics. 2016 Feb 27;17:143. doi: 10.1186/s12864-016-2483-y.   PubMed 26921172     FullText


       
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Participants Sarah R Leist       Helmholtz Center for Infection Research Braunschweig GERMANY
Heike Kollmus       Helmholtz Center for Infection Research Braunschweig GERMANY
Klaus Schughart       Helmholtz Center for Infection Research Braunschweig GERMANY
ContactKlaus Schughart     Klaus.Schughart@helmholtz-hzi.de     Lab web site
Part of a series: • study 1   see Schughart3
• study 2   see Schughart4
• study 3   (this project) Schughart5
Project type Phenotype strain survey data set
MPD identifiersSchughart5     MPD:588
Data changelog No updates/corrections.       Initial release date: 01/2017.
Formatted citation
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Mice infected with influenza A H3N2 virus (one dose) were analyzed for daily weight loss for up to 30 days. The mouse-adapted virus strain influenza A/HK/01/68 was used. Lung weights are also available. Overall survival and mortality rates are available from females and males in Schughart3, and viral loads and leukocyte profiles are available in Schughart4.

Summary of procedures that were conducted
• body weight Influenza A (H3N2) virus vs. controls. Several timepoints.
• organ weights Lung weight. Animals infected with influenza A (H3N2) virus vs. controls.
Mice: inbred   8 strains   ♀   age 8-12wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schughart5 58801 body weight (none) body weight pre-infection   [g]     control group    treated group inbred w/CC8 8 f 8-12wks N=8
    Schughart5 58811 body weight (none) percent change in body weight, control group   [%]     days post-treatment (saline):    1    2    3 inbred w/CC8 8 f 8-12wks N=4
    Schughart5 58821 body weight influenza A (H3N2) virus percent change in body weight, 10 FFU group   [%]     days post-infection:    1    2    3    4    5    6    7    8    9    10    11    12    13    14    18    30 inbred w/CC8 8 f 8-12wks N=9
    Schughart5 58881 organ weights influenza A (H3N2) virus  control lung weight, control group, day 3   [g]  lungwt_ctrl_d3 inbred w/CC8 8 f 10wks N=3
    Schughart5 58883 organ weights influenza A (H3N2) virus lung weight, treated group   [g]     days post-infection:    3    5    8    18    30 inbred w/CC8 8 f 10wks N=4
    Schughart5 58891 organ weights influenza A (H3N2) virus  control relative lung weight, control group, day 3   [%]  lungwtadj_ctrl_d3 inbred w/CC8 8 f 10wks N=3
    Schughart5 58893 organ weights influenza A (H3N2) virus relative lung weight, treated group   [%]     days post-infection:    3    5    8    18    30 inbred w/CC8 8 f 10wks N=4
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