Schughart3: Susceptibility to influenza A (H3N2) viral infection: body weight and survival at three doses in the 8 inbred founder strains of the Collaborative Cross (2013)

Leist SR, Pilzner C, van den Brand JM, Dengler L, Geffers R, Kuiken T, Balling R, Kollmus H, Schughart K. Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics. 2016 Feb 27;17:143. doi: 10.1186/s12864-016-2483-y.   PubMed 26921172     FullText


       
Schughart3 downloads
• Download Schughart3 project data set     one row per animal, one column per trait
• Download Schughart3 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Sarah R Leist       Helmholtz Center for Infection Research Braunschweig GERMANY
Heike Kollmus       Helmholtz Center for Infection Research Braunschweig GERMANY
Klaus Schughart       Helmholtz Center for Infection Research Braunschweig GERMANY
ContactKlaus Schughart     Klaus.Schughart@helmholtz-hzi.de     Lab web site
Part of a series: • study 1   (this project) Schughart3
• study 2   see Schughart4
• study 3   see Schughart5
AcknowledgementsFunding provided by the Helmholtz-Association (Program Infection and Immunity); FluResearchNet (No. 01KI07137) from the German Ministry of Education and Research: Gesellschaft der Freunde der Tierärztlichen Hochschule Hannover
Project type Phenotype strain survey data set
MPD identifiersSchughart3     MPD:571
Data changelog No updates/corrections.       Initial release date: 01/2017.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice infected with influenza A H3N2 virus at three doses were analyzed for subsequent daily weight loss and survival over a period of 14 days. The mouse-adapted virus strain influenza A/HK/01/68 was used. Body weight loss is available for days 1 through 14. Overall survival and mortality rates are also available in this project. Viral loads, lung weights and leukocyte profiles from additional cohorts are available from females in Schughart4 and Schughart5.

Summary of procedures that were conducted
• body weight Influenza A (H3N2) virus (several doses) vs. baseline. Several timepoints.
• health assessment Survival rate, susceptibility, influenza A (H3N2) virus (several doses).
Mice: inbred   8 strains   ♀♂   age 7-13wks   3 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Schughart3 57101 body weight (none) body weight pre-infection   [g]     10 FFU group    2000 FFU group    200000 FFU group inbred w/CC8 8 both 7-13wks N=11
    Schughart3 57111 body weight influenza A (H3N2) virus percent change in body weight, 10 FFU group   [%]     days post-infection:    1    2    3    4    5    6    7    8    9    10    11    12    13    14 inbred w/CC8 8 both 7-13wks N=9
    Schughart3 57131 body weight influenza A (H3N2) virus percent change in body weight, 2000 FFU group   [%]     days post-infection:    1    2    3    4    5    6    7    8    9    10    11    12    13    14 inbred w/CC8 8 both 7-13wks N=9
    Schughart3 57151 body weight influenza A (H3N2) virus percent change in body weight, 200,000 FFU group   [%]     days post-infection:    1    2    3    4    5    6    7    8    9    10    11    12    13    14 inbred 2 both 7-13wks N=12
    Schughart3 57181 health assessment influenza A (H3N2) virus survival, post-infection   [d]     10 FFU group    2000 FFU group    200000 FFU group inbred w/CC8 8 both 7-13wks N=11
    Schughart3 57191 health assessment influenza A (H3N2) virus susceptibility to viral infection (0=resistant, 1=susceptible), mortality rate   [score]     10 FFU group    2000 FFU group    200000 FFU group inbred w/CC8 8 both 7-13wks N=11
    All boxes