Paigen2: Diet effects on plasma lipids and susceptibility to atherosclerosis in 43 inbred strains of mice on high-fat atherogenic diet (under pathogen-free conditions) (2002)

Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.   PubMed 17317875  


       
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Participants Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Karen L Svenson       The Jackson Laboratory Bar Harbor, ME
Luanne L Peters       The Jackson Laboratory Bar Harbor, ME
With: Von Smith R
ContactBeverly Paigen     bev.paigen@jax.org
AffiliationJackson Laboratory Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by NIH HL66611

In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersPaigen2     MPD:99
Data changelog 4 updates/corrections.       Initial release date: 05/2003.
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Animals were evaluated at baseline and then again after 17 wks on high fat (15% fat) diet.

Summary of procedures that were conducted
• histopathology Aortic lesion size histopathology. Baseline vs. high-fat diet (17wks).
• lipid profile Cholesterol, HDL, non-HDL, triglycerides. Baseline vs. high-fat diet (17wks). 4h fast, plasma.
Mice: inbred   43 strains   ♀♂   age 7-9wks, 24-27wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Paigen2 9904 lipid profile high fat diet HDL cholesterol   [mg/dL]     baseline    after 17wks on diet    Δchange inbred w/CC7 41 both 7-9wks N=9
    Paigen2 9905 lipid profile high fat diet non-HDL cholesterol   [mg/dL]     baseline    after 17wks on diet    Δchange inbred w/CC7 41 both 7-9wks N=9
    Paigen2 9906 lipid profile high fat diet total cholesterol   [mg/dL]     baseline    after 17wks on diet    Δchange inbred w/CC7 41 both 7-9wks N=9
    Paigen2 9921 lipid profile high fat diet triglycerides (4h fast)   [mg/dL]     baseline    after 17wks on diet    Δchange inbred w/CC7 41 both 7-9wks N=9
    Paigen2 9924 histopathology high fat diet  17wks fatty streak aortic lesion size   [µm2]  aortic_lesion inbred w/CC7 42 both 25-27wks N=9
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