Project measures / variables set:   Paigen2   HDLC

ID, description, units MPD:9904   HDLC   HDL cholesterol (plasma)   [mg/dL]  
high-fat diet study
Measures • baseline    • after 17wks on diet    • Δchange
Data set, strains Paigen2   inbred w/CC7   42 strains     sex: both     age: 7-9wks
Procedure lipid profile
Comparisonrepeated measures, baseline then treated, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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  OVERLAPPING STRAIN CURVES
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Paigen2 - HDL cholesterol (plasma)



  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   sex 1 50174.5182 50174.5182 144.8739 < 0.0001
between   strain 33 584520.9225 17712.7552 51.1438 < 0.0001
between   sex:strain 33 69266.2034 2098.9759 6.0606 < 0.0001
between   Residuals 511 176975.8729 346.3324
within   group 1 104323.0033 104323.0033 308.6443 < 0.0001
within   group:sex 1 4661.8614 4661.8614 13.7923 0.0002
within   group:strain 33 165256.2112 5007.764 14.8157 < 0.0001
within   group:sex:strain 33 31916.8923 967.1786 2.8614 < 0.0001
within   Residuals 511 172720.0241 338.004

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested		SexAge
Paigen2 9904 lipid profile high-fat diet HDL cholesterol (plasma)   [mg/dL]   baseline  HDLC inbred w/CC7 42 both 7-9wks
Paigen2 9907 lipid profile high-fat diet HDL cholesterol (plasma)   [mg/dL]   after 17wks on diet  HDLC_fat17 inbred w/CC7 41 both 7-9wks
Paigen2 9910 lipid profile high-fat diet HDL cholesterol (plasma)   [mg/dL]   fold change  HDLC_chg inbred w/CC7 41 both 7-9wks (supplemental /
  summary measure)



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