Graubert1: Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice (2006)

Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res. 2006 May 15;66(10):5029-38.   PubMed 16707424  


       
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Participants Timothy A Graubert       Washington University School of Medicine St. Louis, MO
James W Watters       Washington University School of Medicine St. Louis, MO
Howard L McLeod       University of North Carolina Chapel Hill, NC
With: Fenske TS
ContactTimothy A Graubert     graubert@medicine.wustl.edu     Lab web site
AcknowledgementsFunding provided by NIH GM063340

Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type Phenotype strain survey data set
MPD identifiersGraubert1     MPD:116
Data changelog 2 updates/corrections.       Initial release date: 07/2008.
Formatted citation
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An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined. Animals were evaluated for baseline hematology. Some animals were treated with N-nitroso-N-ethylurea (ENU) and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system. There were two cohorts: 1) controls; 2) treated with 100 mg/kg body weight ENU i.p.

Summary of procedures that were conducted
• complete blood count Hematology.
• histopathology Tumor growth frequency rates. ENU mutagen vs. control.
Mice: inbred   20 strains   ♀♂   age 9wks; 3-16mo   2 cohorts

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Graubert1 11601 complete blood count (none) white blood cell count (WBC; per volume x 103)   [n/µL]  WBC inbred 20 both 9wks N=12
    Graubert1 11602 complete blood count (none) neutrophil count (NEUT; units per volume x 103)   [n/µL]  NEUT inbred 20 both 9wks N=12
    Graubert1 11603 complete blood count (none) lymphocyte count (LYMP; units per volume x 103)   [n/µL]  LYMP inbred 20 both 9wks N=12
    Graubert1 11604 complete blood count (none) neutrophil differential (percent of total WBC)   [%]  pct_NEUT inbred 20 both 9wks N=12
    Graubert1 11605 complete blood count (none) lymphocyte differential (percent of total WBC)   [%]  pct_LYMP inbred 20 both 9wks N=12
    Graubert1 11607 complete blood count (none) hemoglobin (HGB)   [g/dL]  HGB inbred 20 both 9wks N=12
    Graubert1 11608 complete blood count (none) platelet count (PLT; units per volume x 103)   [n/µL]  PLT inbred 20 both 9wks N=12
    Graubert1 11616 histopathology ENU lung adenoma frequency rate   [score]     control    ENU inbred 20 both 13-68wks N=6
    Graubert1 11617 histopathology ENU lung carcinoma frequency rate   [score]     control    ENU inbred 20 both 13-68wks N=6
    Graubert1 11618 histopathology ENU lymphoid tumor frequency rate   [score]     control    ENU inbred 20 both 13-68wks N=6
    Graubert1 11619 histopathology ENU myeloid tumor frequency rate   [score]     control    ENU inbred 20 both 13-68wks N=6
    Graubert1 11620 histopathology ENU gastrointestinal (GI) tumor frequency rate   [score]     control    ENU inbred 20 both 13-68wks N=6
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