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Project data set: Naggert1   (2003)

Project Diet effects on bone mineral density and content, body composition, and plasma glucose, leptin, and insulin levels in 43 inbred strains of mice on a high-fat atherogenic diet

Study design: all mice subjected to an intervention; 1 cohort.
43 strains tested     female male     Test age: various

Investigators Naggert J, Svenson KL, Smith RV, Paigen B, Peters LL   [Details, papers]
Heart, Lung, and Blood Center

Protocol View phenotyping protocol and methods

Naggert1
measurements



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blood — clinical chemistry         metabolic panel  
Naggert1
glucose (plasma GLU, 4h fast) [mg/dL]     baseline and  high-fat diet 17wks
      • baseline   • after 17wks on diet   • Δchange    • comparison  
43 strains   age 7-9wks
                at baseline

  Inbred
 
body composition         DXA  
Naggert1
percent of tissue mass that is fat, head excluded   [%]   high-fat diet   8wks
43 strains   age 15-17wks
  Inbred
Naggert1
weight of fat portion of tissue mass, head excluded   [g]   high-fat diet   8wks
43 strains   age 15-17wks
  Inbred
Naggert1
weight of lean portion of tissue mass, head excluded   [g]   high-fat diet   8wks
43 strains   age 15-17wks
  Inbred
Naggert1
total tissue mass, head excluded   [g]   high-fat diet   8wks
43 strains   age 15-17wks
  Inbred
 
body weight         scales  
Naggert1
body weight   [g]   high-fat diet   8wks
43 strains   age 15-17wks
  Inbred
 
bone — mineral density and content — whole body without head         DXA  
Naggert1
bone mineral density and content   high-fat diet   8wks
      • BMD   • BMC 
43 strains   age 15-17wks
  Inbred
 
endocrine — hormones         ELISA  
Naggert1
insulin   [ng/mL]   high-fat diet   18wks
43 strains   age 25-27wks
  Inbred
Naggert1
leptin   [pg/mL]   high-fat diet   18wks
43 strains   age 25-27wks
  Inbred



Number of mice tested per strain, for each measurement

  
Changelog There have been 6 updates or corrections to the data set since MPD release in May 2003  
Reference
Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29.     PubMed 18230669     MGI


Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.     PubMed 17317875     MGI

Related papers
Mice
Strain and animal info
Note
The insulin and leptin animal values are based on multiple test passes.
Note
Please note: Low sample sizes (N < 5) are present. [View table]
Note
Some measurements were derived by MPD staff,
based on supplied data. [View list]

Naggert1
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also the MPD download center for more general data download options.





 




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