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Project data set: Maurer1   (2009)

Project Drug study: Cardiovascular response to beta-adrenergic blockade or activation in males of 23 inbred strains of mice

An investigation of the cardiovascular effect of a β-adrenergic receptor blocker and a β-agonist in four treatment group cohorts: (1) Control; (2) Treated with 10 mg/kg/day atenolol for 2 wks; (3) Treated with 1 mg/kg/day isoproterenol for 2 wks; (4) Treated with 10 mg/kg/day isoproterenol for 2 wks.

Study design: control vs. intervention in various doses; 4 cohorts.
23 strains tested     male only     Test age: 7-13wks
Sample sizes are 10.4 on average. ... Caution, some N ≤ 2 are present  [details]

Investigators Maurer F, Beckmann J, Abriel H, Pedrazzini T     [Project details, papers, citing]

Protocol View phenotyping protocol and methods

Maurer1
measurements



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body weight         scales  
Maurer1
body weight at start of testing, all cohorts combined   [g] 23 strains   age 7-13wks
  Inbred
Maurer1
fold change in body weight over testing period [ratio]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
 
cardiovascular — blood pressure         tail cuff  
Maurer1
systolic blood pressure [mmHg]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
 
cardiovascular — ECG parameters — unconscious         ECG  
Maurer1
amplitude of P-wave [mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
amplitude of Q-wave [mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
amplitude of R-wave [mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
amplitude of S-wave [mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
duration P-wave [ms]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
interval PR [ms]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
interval RR [ms]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
interval QRS [ms]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
interval QT [ms]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
interval ST [ms]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
area of P-wave [ms*mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
area of QRS [ms*mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
area of QTc [ms*mV]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
 
cardiovascular — heart rate — conscious         tail cuff  
Maurer1
pulse rate [n/min]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
 
cardiovascular — heart rate — unconscious         ECG  
Maurer1
heart rate [n/min]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
 
cardiovascular — heart weight         scales  
Maurer1
heart weight [mg]     control and  atenolol, isoproterenol      
  weight:    • control     • atenolol 10mg     • isoprot 1mg     • isoprot 10mg      comparison        
  normalized:    • control     • atenolol 10mg     • isoprot 1mg     • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
atria weight [mg]     control and  atenolol, isoproterenol      
  weight:    • control     • atenolol 10mg     • isoprot 1mg     • isoprot 10mg      comparison        
  normalized:    • control     • atenolol 10mg     • isoprot 1mg     • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
ventricle (both) weight [mg]     control and  atenolol, isoproterenol      
  weight:    • control     • atenolol 10mg     • isoprot 1mg     • isoprot 10mg      comparison        
  normalized:    • control     • atenolol 10mg     • isoprot 1mg     • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred
Maurer1
atria weight to ventricle weight ratio [ratio]     control and  atenolol, isoproterenol      
• control   • atenolol 10mg   • isoprot 1mg   • isoprot 10mg      comparison  
23 strains   age 7-13wks
  Inbred


local experiment parameter  
Maurer1
age at testing   [wks] 23 strains  
  Inbred


  
Reference
Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Abriel H, Pedrazzini T, Beckmann JS, Bergmann S, Maurer F. Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. PLoS One. 2009 Aug 12;4(8):e6610.     PubMed 19672458     MGI     FullText

See also a related paper


Mice

Strain and animal info

Citing

Cite this MPD data set

Changelog

No updates or corrections have been posted since MPD release in Mar 2010  

Note

A number of data points were withdrawn or not available for various reasons as explained in the protocol. In the project data set the missing data code "WD" is used for all of these missing data points.

Note

Some measurements were derived by MPD staff,
based on supplied data. [View list]

Note

Some measurements are a mixture of + and – values. [View list]

Note

Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics [View list]

Maurer1
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
Supplemental data are available

 See also MPD's general data download page for other options.





 




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