MPD: Project measures / variables set: Maurer1 S

Project measures / variables set: Maurer1 S_amp

ID, description, units	MPD:33225 S_amp amplitude of S-wave [mV] atenolol, isoproterenol study
Measures	• control • atenolol 10mg • isoprot 1mg • isoprot 10mg
Data set, strains	Maurer1 inbred 23 strains sex: m age: 7-13wks
Procedure	ECG
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000231 heart excitatory physiology trait VT:0010487 response to xenobiotic stimulus trait MA:0000072 heart MP:0008872 abnormal physiological response to xenobiotic MP:0011920 abnormal S wave

Values Means Δ Means Z-scores

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Maurer1 - amplitude of S-wave

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	3	0.0796	0.0265	1.4919	0.2155
group:strain	60	1.2304	0.0205	1.153	0.2076
Residuals	685	12.1834	0.0178
strain	20	10.8908	0.5445	30.6161	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Maurer1	33225	ECG	atenolol, isoproterenol	amplitude of S-wave [mV] control S_amp_ctrl	inbred	23	m	7-13wks
Maurer1	33226	ECG	atenolol, isoproterenol	amplitude of S-wave [mV] atenolol 10mg S_amp_at	inbred	21	m	7-13wks
Maurer1	33227	ECG	atenolol, isoproterenol	amplitude of S-wave [mV] isoprot 1mg S_amp_iso1	inbred	22	m	7-13wks
Maurer1	33228	ECG	atenolol, isoproterenol	amplitude of S-wave [mV] isoprot 10mg S_amp_iso10	inbred	22	m	7-13wks