MPD: Project measures / variables set: Maurer1 Q

Project measures / variables set: Maurer1 Q_amp

ID, description, units	MPD:33217 Q_amp amplitude of Q-wave [mV] atenolol, isoproterenol study
Measures	• control • atenolol 10mg • isoprot 1mg • isoprot 10mg
Data set, strains	Maurer1 inbred 23 strains sex: m age: 7-13wks
Procedure	ECG
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000231 heart excitatory physiology trait VT:0010487 response to xenobiotic stimulus trait MA:0000072 heart MP:0008872 abnormal physiological response to xenobiotic MP:0010515 abnormal Q wave

Values Means Δ Means Z-scores

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Maurer1 - amplitude of Q-wave

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	3	0.0506	0.0169	9.4175	< 0.0001
group:strain	60	0.2132	0.0036	1.9836	< 0.0001
Residuals	691	1.2378	0.0018
strain	20	0.5087	0.0254	14.2002	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Maurer1	33217	ECG	atenolol, isoproterenol	amplitude of Q-wave [mV] control Q_amp_ctrl	inbred	23	m	7-13wks
Maurer1	33218	ECG	atenolol, isoproterenol	amplitude of Q-wave [mV] atenolol 10mg Q_amp_at	inbred	22	m	7-13wks
Maurer1	33219	ECG	atenolol, isoproterenol	amplitude of Q-wave [mV] isoprot 1mg Q_amp_iso1	inbred	23	m	7-13wks
Maurer1	33220	ECG	atenolol, isoproterenol	amplitude of Q-wave [mV] isoprot 10mg Q_amp_iso10	inbred	23	m	7-13wks