Wiltshire4: Toxicity of four anti-cancer agents tested in vitro in immune cells from 36 inbred mouse strains (2015)

Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS, Wiltshire T. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmgenomics Pers Med. 2015 Feb 26;8:81-98. doi: 10.2147/PGPM.S73312. eCollection 2015.   PubMed 25897258     FullText


         
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Investigators Tim Wiltshire       University of North Carolina,  Chapel Hill, NC
Participants Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS
ContactTim Wiltshire     timw@unc.edu     Lab web site
Project type Phenotype strain survey data set
MPD identifiersWiltshire4     MPD:524
Data changelog No updates/corrections.       Initial release date: 01/2016.
Formatted citation
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The anti-cancer agents studied are: BEZ235, doxorubicin, idarubicin, and selumetinib. Cells were harvested from 4 mice per strain. The investigators normalized the individual animal data such that the controls for each strain / drug / cell analysis group averaged out to 100.0.

Experimental groups in this study:
• BEZ235     • Doxorubicin     • Idarubicin     • Selumetinib    

Procedures conducted:
• immune cell quantification  In vitro study of 4 cancer chemotherapies (BEZ235, doxorubicin, idarubicin, selumetinib) vs. control. Effect on immune cells. Normalized data.

Mice: inbred w/CC7   36 strains   ♂   age 10wks   4 experimental groups

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    Wiltshire4 immune cell quantification BEZ235 B cells, percent viability   [%]  Bcells_BEZ   52401     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 immune cell quantification BEZ235 T cells, percent viability   [%]  Tcells_BEZ   52407     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 immune cell quantification BEZ235 monocytes, percent viability   [%]  monocytes_BEZ   52413     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
    Wiltshire4 immune cell quantification doxorubicin B cells, percent viability   [%]  Bcells_Dox   52421     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 immune cell quantification doxorubicin T cells, percent viability   [%]  Tcells_Dox   52427     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 immune cell quantification doxorubicin monocytes, percent viability   [%]  monocytes_Dox   52433     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 immune cell quantification idarubicin B cells, percent viability   [%]  Bcells_Ida   52441     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 immune cell quantification idarubicin T cells, percent viability   [%]  Tcells_Ida   52447     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 immune cell quantification idarubicin monocytes, percent viability   [%]  monocytes_Ida   52453     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 35 m 10wks N=4
    Wiltshire4 immune cell quantification selumetinib B cells, percent viability   [%]  Bcells_Sel   52461     dose [µM]:    control    0.046    0.137    1.235    11.1    100 inbred w/CC7 34 m 10wks N=4
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