MPD: Project measures / variables set: Wiltshire4 Tcells

Project measures / variables set: Wiltshire4 Tcells_Sel

ID, description, units	MPD:52467 Tcells_Sel T cells, percent viability [%] selumetinib study
Measures	• dose [µM]: • control • 0.046 • 0.137 • 1.235 • 11.1 • 100
Data set, strains	Wiltshire4 inbred w/CC7 34 strains sex: m age: 10wks
Procedure	immune cell quantification
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0006387 T cell quantity VT:0010487 response to xenobiotic stimulus trait MA:0000141 spleen MP:0006387 abnormal T cell number MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Wiltshire4 - T cells, percent viability

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	5	64.9804	12.9961	0.7857	0.5602
dose:strain	165	1902.2288	11.5287	0.697	0.9972
Residuals	594	9824.9155	16.5403
strain	33	4349.7393	131.8103	7.9691	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Wiltshire4	52467	immune cell quantification	selumetinib	T cells, percent viability [%] control Tcells_Sel_ctrl	inbred w/CC7	34	m	10wks
Wiltshire4	52468	immune cell quantification	selumetinib	T cells, percent viability [%] dose: 0.046 µM Tcells_Sel_A	inbred w/CC7	34	m	10wks
Wiltshire4	52469	immune cell quantification	selumetinib	T cells, percent viability [%] dose: 0.137 µM Tcells_Sel_B	inbred w/CC7	34	m	10wks
Wiltshire4	52470	immune cell quantification	selumetinib	T cells, percent viability [%] dose: 1.235 µM Tcells_Sel_C	inbred w/CC7	34	m	10wks
Wiltshire4	52471	immune cell quantification	selumetinib	T cells, percent viability [%] dose: 11.1 µM Tcells_Sel_D	inbred w/CC7	34	m	10wks
Wiltshire4	52472	immune cell quantification	selumetinib	T cells, percent viability [%] dose: 100 µM Tcells_Sel_E	inbred w/CC7	34	m	10wks