MPD: Project measures / variables set: Wiltshire4 monocytes

Project measures / variables set: Wiltshire4 monocytes_BEZ

ID, description, units	MPD:52413 monocytes_BEZ monocytes, percent viability [%] BEZ235 study
Measures	• dose [µM]: • control • 0.046 • 0.137 • 1.235 • 11.1 • 100
Data set, strains	Wiltshire4 inbred w/CC7 34 strains sex: m age: 10wks
Procedure	immune cell quantification
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000223 monocyte quantity VT:0010487 response to xenobiotic stimulus trait MA:0000141 spleen MP:0008872 abnormal physiological response to xenobiotic MP:0012441 abnormal monocyte cell number

Values Means Δ Means Z-scores

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Wiltshire4 - monocytes, percent viability

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	5	42200.3415	8440.0683	50.2473	< 0.0001
dose:strain	165	105247.2014	637.8618	3.7975	< 0.0001
Residuals	594	99774.5843	167.9707
strain	33	99123.1556	3003.732	17.8825	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Wiltshire4	52413	immune cell quantification	BEZ235	monocytes, percent viability [%] control monocytes_BEZ_ctrl	inbred w/CC7	34	m	10wks
Wiltshire4	52414	immune cell quantification	BEZ235	monocytes, percent viability [%] dose: 0.046 µM monocytes_BEZ_A	inbred w/CC7	34	m	10wks
Wiltshire4	52415	immune cell quantification	BEZ235	monocytes, percent viability [%] dose: 0.137 µM monocytes_BEZ_B	inbred w/CC7	34	m	10wks
Wiltshire4	52416	immune cell quantification	BEZ235	monocytes, percent viability [%] dose: 1.235 µM monocytes_BEZ_C	inbred w/CC7	34	m	10wks
Wiltshire4	52417	immune cell quantification	BEZ235	monocytes, percent viability [%] dose: 11.1 µM monocytes_BEZ_D	inbred w/CC7	34	m	10wks
Wiltshire4	52418	immune cell quantification	BEZ235	monocytes, percent viability [%] dose: 100 µM monocytes_BEZ_E	inbred w/CC7	34	m	10wks