The extinction rate among pre-CC lines has been estimated at 95%. Male infertility played a large role in extinction as 47% of extinct lines had males that were infertile. Males from extinct lines had high variability in reproductive organ size, low sperm counts, low sperm motility, and a high rate of vacuolization of seminiferous tubules. In this study, the investigators supplied data comparing genetically fertile versus genetically infertile extinct lines. See also Odet1 and Odet2 for male fertility phenotypes in CC founder strains.

Investigators	John R Shorter       University of North Carolina,  Chapel Hill, NC Deborah A O'Brien       University of North Carolina,  Chapel Hill, NC Fernando Pardo-Manuel de Villena       University of North Carolina,  Chapel Hill, NC
Participants	Odet F, Aylor DL, Pan W, Kao CY, Fu CP, Morgan AP, Greenstein S, Bell TA, Stevans AM, Feathers RW, Patel S, Cates SE, Shaw GD, Miller DR, Chesler EJ, McMillian L
Contact	Fernando Pardo-Manuel de Villena     fernando@med.unc.edu     Lab web site
Project type	Phenotype archive study
MPD identifiers	Shorter1     MPD:600
Data changelog	No updates/corrections.       Initial release date: 08/2017.
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