Korstanje2: Aging study: Glomerular mesangial matrix expansion in 29 inbred strains of mice (2013)

Noordmans GA, Caputo CR, Huang Y, Sheehan SM, Bulthuis M, Heeringa P, Hillebrands JL, van Goor H, Korstanje R. Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene. J Am Soc Nephrol. 2013 Dec;24(12):1995-200doi: 10.1681/ASN.2012080838. Epub 2013 Sep 5.   PubMed 24009241     FullText


       
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Participants Ron Korstanje       The Jackson Laboratory Bar Harbor, ME
With: Noordmans GA, Caputo CR, Huang Y, Sheehan SM, Bulthuis M, Heeringa P, Hillebrands JL, van Goor H
ContactRon Korstanje     ron.korstanje@jax.org     Lab web site
AffiliationJackson Laboratory Nathan Shock Center
AcknowledgementsFunding provided by NIH GM076468, AG038070, CA034196; Jan Dekker and Ludgardina Bouwman Foundation
Project type Phenotype strain survey data set
MPD identifiersKorstanje2     MPD:510
Data changelog No updates/corrections.       Initial release date: 05/2014.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Structural changes in glomeruli of male mice were examined. Older mice (20 mo) were tested first. Then for strains showing an effect, mice at younger ages (6 mo, 12 mo) were examined.

Summary of procedures that were conducted
• histopathology Kidney pathology. Aging study, 6mo, 12mo, 20mo.
Mice: inbred   29 strains   ♂   age 12, 18, 24 mo   3 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Korstanje2 51001 histopathology (none) percent of glomeruli exhibiting mesangial matrix expansion   [%]     6mo    12mo    20mo inbred 7 m None N=6
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