Gould3: Drug study: Effects of nicotine withdrawal on fear conditioning and other behaviors in males of 8 inbred mouse strains (2011)

Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6.   PubMed 21822688  


       
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• Gould3 supplementary data
Participants George S Portugal       Columbia University New York, NY
Thomas J Gould       Temple University Philadelphia, PA
With: Wilkinson DS, Kenney JW, Sullivan C
ContactThomas J Gould     tgould@temple.edu     Lab web site
Part of a series: • nicotine acute and chronic study groups   see Gould2
• nicotine withdrawal study group   (this project) Gould3
AcknowledgementsFunding provided by NIH DA017949, DA024787, CA143187
Project type Phenotype strain survey data set
MPD identifiersGould3     MPD:473
Data changelog No updates/corrections.       Initial release date: 05/2013.
Formatted citation
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This project contains the withdrawal study component from the Gould nicotine study. Cohorts here include saline controls and nicotine dose groups of 3, 6.3, and 12 mg/kg.

Summary of procedures that were conducted
• behavior observation Observed measures of anxiety during nicotine withdrawal. Nicotine (several high doses) vs. control.
• elevated plus maze Measures of anxiety during nicotine withdrawal. Nicotine (several high doses) vs. control.
• fear conditioning test Contextual fear, cued fear during nicotine withdrawal. Nicotine (high and several lower doses) vs. control.
Mice: inbred   8 strains   ♂   age 8-12wks   4 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Gould3 47301 behavior observation nicotine withdrawal group: grooming   [n]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=11
    Gould3 47306 behavior observation nicotine withdrawal group: scratching   [n]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=11
    Gould3 47311 behavior observation nicotine withdrawal group: jumping   [n]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=11
    Gould3 47321 elevated plus maze nicotine withdrawal group: time in closed arms   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=10
    Gould3 47326 elevated plus maze nicotine withdrawal group: time in open arms   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=10
    Gould3 47331 elevated plus maze nicotine withdrawal group: time in center   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=10
    Gould3 47341 fear conditioning test nicotine withdrawal group: conditioning: immediate fear   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12
    Gould3 47346 fear conditioning test nicotine withdrawal group: conditioning: contextual fear   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12
    Gould3 47361 fear conditioning test nicotine withdrawal group: cued fear: pre-cue   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12
    Gould3 47366 fear conditioning test nicotine withdrawal group: cued fear: cue   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12
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