MPD: Project measures / variables set: Gould3 FC

Project measures / variables set: Gould3 FC_context

ID, description, units	MPD:47346 FC_context withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] nicotine study
Measures	• control • nicotine dose (mg) • 3 • 6.3 • 12
Data set, strains	Gould3 inbred 8 strains sex: m age: 8-12wks
Procedure	fear conditioning test
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0010529 contextual fear conditioning behavior trait VT:0010715 fear-related behavior trait VT:0010721 response to nicotine trait VT:0010722 withdrawal response to addictive substance trait MP:0001469 abnormal contextual conditioning behavior MP:0003106 abnormal fear-related response MP:0009774 abnormal behavioral withdrawal response MP:0020160 abnormal behavioral response to nicotine

Values Means Δ Means Z-scores

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Gould3 - withdrawal study group, percent immobility in training chamber, 24h after fear conditioning

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	10368.6857	3456.2286	38.616	< 0.0001
dose:strain	21	4775.5722	227.4082	2.5408	0.0003
Residuals	336	30072.8458	89.5025
strain	7	72746.5293	10392.3613	116.1125	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould3	47346	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] control FC_context_0	inbred	8	m	8-12wks
Gould3	47347	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] dose 3 mg FC_context_3	inbred	8	m	8-12wks
Gould3	47348	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] dose 6.3 mg FC_context_6	inbred	8	m	8-12wks
Gould3	47349	fear conditioning test	nicotine	withdrawal study group, percent immobility in training chamber, 24h after fear conditioning [%] dose 12 mg FC_context_12	inbred	8	m	8-12wks