MPD: Data set: Brown2

References (chronological)

1. Wong AA, Brown RE. Visual detection, pattern discrimination and visual acuity in 14 strains of mice. Genes Brain Behav. 2006 Jul;5(5):389-403. PubMed 16879633

2. Brown RE, Wong AA. The influence of visual ability on learning and memory performance in 13 strains of mice. Learn Mem. 2007 Mar 8;14(3):134-44. Print 2007 Mar. PubMed 17351136 FullText

3. O'Leary TP, Savoie V, Brown RE. Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze. Behav Brain Res. 2011 Jan 20;216(2):531-42. Epub 2010 Aug 27. PubMed 20801160

Brown2 downloads
• Download Brown2 project data set animal data, as uploaded
• Download Brown2 animal data matrix with factor-related expansion applied as necessary
• Download Brown2 strain means, SD, N, etc. one row per strain/sex/measure
• Brown2 supplementary data

Ontology terms mapped to Brown2 measures:

MP:0001460 abnormal olfactory discrimination memory
MP:0001516 abnormal motor coordination/balance
MP:0002063 abnormal learning/memory/conditioning
MP:0008414 abnormal spatial reference memory
MP:0011832 abnormal visual acuity
VT:0001516 motor coordination/balance trait
VT:0002001 visual acuity trait
VT:0002063 learning/memory/conditioning trait
VT:0010727 spatial reference memory trait
VT:0010729 olfactory discrimination memory trait

Investigators	Richard E Brown Dalhousie University, Halifax, Nova Scotia CANADA Heather M Schellinck Dalhousie University, Halifax, Nova Scotia CANADA Rhian K Gunn Dalhousie University, Halifax, Nova Scotia CANADA Aimee A Wong Dalhousie University, Halifax, Nova Scotia CANADA Timothy P O'Leary Dalhousie University, Halifax, Nova Scotia CANADA
Participants	Currie L, Hoffman N, Savoie V
Contact	Richard E Brown rebrown@dal.ca Lab web site
Acknowledgements	Funding provided by Natural Sciences and Engineering Research Council of Canada (NSERC 7441); Generous funds from AstraZeneca R&D Boston were used to defray the cost of mice through the Mouse Phenome Project.
Project type	Phenotype strain survey data set
MPD identifiers	Brown2 MPD:225
Data changelog	No updates/corrections. Initial release date: 02/2008.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

A set of definitions is available.

Procedures conducted:

• Barnes circular maze		Spatial learning and memory.
• Morris water maze		Spatial learning and memory.
• rotarod		Latency to fall from accelerating rotarod. 7 day trials.
• visual water box		Spatial learning and memory.
• olfactory discrimination task		Olfactory-related learning and memory.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Brown2:5	Brown2	Morris water maze	(none)	acquistion training mean distance traveled to find hidden platform, day 3 [cm] acq_dist_d3 22505	inbred	14	both	10-18wks	N=9

Brown2:6	Brown2	Morris water maze	(none)	reversal training mean distance traveled to find hidden platform, day 3 [cm] rev_dist_d3 22506	inbred	14	both	10-18wks	N=9

Brown2:7	Brown2	Morris water maze	(none)	acquisition training mean velocity, day3 [cm/s] acq_vel_d3 22507	inbred	14	both	10-18wks	N=9

Brown2:8	Brown2	Morris water maze	(none)	reversal training mean velocity, day 3 [cm/s] rev_vel_d3 22508	inbred	14	both	10-18wks	N=9

Brown2:11	Brown2	Barnes circular maze	(none)	acquisition training mean errors [n] acq_err 22511 day1 day4	inbred	13	both	10-18wks	N=12

Brown2:13	Brown2	Barnes circular maze	(none)	reversal training mean errors [n] rev_err 22513 day1 day4	inbred	13	both	10-18wks	N=12

Brown2:15	Brown2	Barnes circular maze	(none)	acquisition training mean latency to escape [s] acq_lat 22515 day1 day4	inbred	13	both	10-18wks	N=12

Brown2:17	Brown2	Barnes circular maze	(none)	reversal training mean latency to escape [s] rev_lat 22517 day1 day4	inbred	13	both	10-18wks	N=12

Brown2:19	Brown2	Barnes circular maze	(none)	probe trial correct quadrant total entries [n] probe_corr_ent 22519	inbred	13	both	10-18wks	N=11

Brown2:20	Brown2	Barnes circular maze	(none)	probe trial correct quadrant duration [s] probe_corr_dur 22520	inbred	13	both	10-18wks	N=11

Brown2:21	Brown2	Barnes circular maze	(none)	probe trial percent correct quadrant [%] probe_corr_pct 22521	inbred	13	both	10-18wks	N=11

Brown2:31	Brown2	olfactory discrimination task	(none)	percent digging odor pot, conditioned stimulus lemon [%] odorL_dig_pct 22531	inbred	13	both	10-18wks	N=5

Brown2:32	Brown2	olfactory discrimination task	(none)	percent digging odor pot, conditioned stimulus rose [%] odorR_dig_pct 22532	inbred	13	both	10-18wks	N=5

Brown2:37	Brown2	olfactory discrimination task	(none)	total time spent digging [s] dig_tot 22537	inbred	13	both	10-18wks	N=12

Brown2:41	Brown2	Morris water maze	(none)	acquistion training mean latency to find hidden platform, day 3 [s] acq_lat_d3 22541	inbred	14	both	10-18wks	N=10

Brown2:42	Brown2	Morris water maze	(none)	reversal training mean latency to find hidden platform, day 3 [s] rev_lat_d3 22542	inbred	14	both	10-18wks	N=10

Brown2:43	Brown2	Morris water maze	(none)	probe trial duration, correct quadrant [s] probe_quad_corr 22543	inbred	14	both	10-18wks	N=10

Brown2:44	Brown2	Morris water maze	(none)	probe trial percent time, correct quadrant [%] MWMprobe_corr_pct 22544	inbred	14	both	10-18wks	N=10

Brown2:45	Brown2	Morris water maze	(none)	mean time within pool edge, across all aquistion and reversal trials [s] thigmotaxia_ave 22545	inbred	14	both	10-18wks	N=10

Brown2:46	Brown2	Morris water maze	(none)	mean latency to find visible platform [s] vis_lat 22546	inbred	14	both	10-18wks	N=10

Brown2:51	Brown2	visual water box	(none)	visual discrimination, detection percent correct performance, 0.17 grating threshold, day 8 [%] pct_vis_detec_d8 22551	inbred	14	both	10-18wks	N=7

Brown2:52	Brown2	visual water box	(none)	visual discrimination, pattern discrimination, percent correct performance, 0.17 grating threshold, day 8 [%] pct_pat_disc_d8 22552	inbred	14	both	10-18wks	N=7

Brown2:53	Brown2	visual water box	(none)	visual acuity, percent correct performance [%] pct_vis_acuit 22553 grating threshold: 0.17 (low) 0.32 0.64 (high)	inbred	14	both	10-18wks	N=7

Brown2:55	Brown2	visual water box	(none)	visual discrimination, detection mean latency to reach cued platform, day 8 [s] vis_detec_ave_d8 22555	inbred	14	both	10-18wks	N=7

Brown2:56	Brown2	visual water box	(none)	visual discrimination, pattern discrimination mean latency to reach cued platform, day 8 [s] pat_disc_ave_d8 22556	inbred	14	both	10-18wks	N=7

Brown2:57	Brown2	visual water box	(none)	latency to reach cued platform [s] vis_acuit 22557 grating threshold: 0.17 (low) 0.32 0.64 (high) overall mean	inbred	14	both	10-18wks	N=7

Brown2:61	Brown2	rotarod	(none)	latency to fall from accelerating rotarod (8 rpm/min) [s] fall_ave 22561 day1 day2 day3 day4 day5 day6 day7	inbred	12	both	10-18wks	N=12

Brown2:70	Brown2	olfactory discrimination task	(none)	percent digging pooled across training conditions (Lemon CS+ plus Rose CS+) [%] CS+dig_pct_pooled 22570	inbred	13	both	10-18wks	N=11

Brown2: Visual ability and spatial, motor and olfactory learning and memory in 14 inbred strains of mice (2004)

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