Brown2: Visual ability and spatial, motor and olfactory learning and memory in 14 inbred strains of mice (2004)

References   (chronological)

1.   Wong AA, Brown RE. Visual detection, pattern discrimination and visual acuity in 14 strains of mice. Genes Brain Behav. 2006 Jul;5(5):389-403.   PubMed 16879633  

2.   Brown RE, Wong AA. The influence of visual ability on learning and memory performance in 13 strains of mice. Learn Mem. 2007 Mar 8;14(3):134-44. Print 2007 Mar.   PubMed 17351136     FullText

3.   O'Leary TP, Savoie V, Brown RE. Learning, memory and search strategies of inbred mouse strains with different visual abilities in the Barnes maze. Behav Brain Res. 2011 Jan 20;216(2):531-42. Epub 2010 Aug 27.   PubMed 20801160  


       
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Participants Richard E Brown       Dalhousie University Halifax, Nova Scotia CANADA
Heather M Schellinck       Dalhousie University Halifax, Nova Scotia CANADA
Rhian K Gunn       Dalhousie University Halifax, Nova Scotia CANADA
Aimee A Wong       Dalhousie University Halifax, Nova Scotia CANADA
Timothy P O'Leary       Dalhousie University Halifax, Nova Scotia CANADA
With: Currie L, Hoffman N, Savoie V
ContactRichard E Brown     rebrown@dal.ca     Lab web site
AcknowledgementsFunding provided by Natural Sciences and Engineering Research Council of Canada (NSERC 7441); Generous funds from AstraZeneca R&D Boston were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersBrown2     MPD:225
Data changelog No updates/corrections.       Initial release date: 02/2008.
Formatted citation
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A set of definitions is available.

Summary of procedures that were conducted
• Barnes circular maze Spatial learning and memory.
• Morris water maze Spatial learning and memory.
• rotarod Latency to fall from accelerating rotarod. 7 day trials.
• visual water box Spatial learning and memory.
• olfactory discrimination task Olfactory-related learning and memory.
Mice: inbred   14 strains   ♀♂   age 10-18wks   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Brown2 22505 Morris water maze (none) acquistion training mean distance traveled to find hidden platform, day 3   [cm]  acq_dist_d3 inbred 14 both 10-18wks N=9
    Brown2 22506 Morris water maze (none) reversal training mean distance traveled to find hidden platform, day 3   [cm]  rev_dist_d3 inbred 14 both 10-18wks N=9
    Brown2 22507 Morris water maze (none) acquisition training mean velocity, day3   [cm/s]  acq_vel_d3 inbred 14 both 10-18wks N=9
    Brown2 22508 Morris water maze (none) reversal training mean velocity, day 3   [cm/s]  rev_vel_d3 inbred 14 both 10-18wks N=9
    Brown2 22511 Barnes circular maze (none) acquisition training mean errors   [n]     day1    day4 inbred 13 both 10-18wks N=12
    Brown2 22513 Barnes circular maze (none) reversal training mean errors   [n]     day1    day4 inbred 13 both 10-18wks N=12
    Brown2 22515 Barnes circular maze (none) acquisition training mean latency to escape   [s]     day1    day4 inbred 13 both 10-18wks N=12
    Brown2 22517 Barnes circular maze (none) reversal training mean latency to escape   [s]     day1    day4 inbred 13 both 10-18wks N=12
    Brown2 22519 Barnes circular maze (none) probe trial correct quadrant total entries   [n]  probe_corr_ent inbred 13 both 10-18wks N=11
    Brown2 22520 Barnes circular maze (none) probe trial correct quadrant duration   [s]  probe_corr_dur inbred 13 both 10-18wks N=11
    Brown2 22521 Barnes circular maze (none) probe trial percent correct quadrant   [%]  probe_corr_pct inbred 13 both 10-18wks N=11
    Brown2 22531 olfactory discrimination task (none) percent digging odor pot, conditioned stimulus lemon   [%]  odorL_dig_pct inbred 13 both 10-18wks N=5
    Brown2 22532 olfactory discrimination task (none) percent digging odor pot, conditioned stimulus rose   [%]  odorR_dig_pct inbred 13 both 10-18wks N=5
    Brown2 22537 olfactory discrimination task (none) total time spent digging   [s]  dig_tot inbred 13 both 10-18wks N=12
    Brown2 22541 Morris water maze (none) acquistion training mean latency to find hidden platform, day 3   [s]  acq_lat_d3 inbred 14 both 10-18wks N=10
    Brown2 22542 Morris water maze (none) reversal training mean latency to find hidden platform, day 3   [s]  rev_lat_d3 inbred 14 both 10-18wks N=10
    Brown2 22543 Morris water maze (none) probe trial duration, correct quadrant   [s]  probe_quad_corr inbred 14 both 10-18wks N=10
    Brown2 22544 Morris water maze (none) probe trial percent time, correct quadrant   [%]  MWMprobe_corr_pct inbred 14 both 10-18wks N=10
    Brown2 22545 Morris water maze (none) mean time within pool edge, across all aquistion and reversal trials   [s]  thigmotaxia_ave inbred 14 both 10-18wks N=10
    Brown2 22546 Morris water maze (none) mean latency to find visible platform   [s]  vis_lat inbred 14 both 10-18wks N=10
    Brown2 22551 visual water box (none) visual discrimination, detection percent correct performance, 0.17 grating threshold, day 8   [%]  pct_vis_detec_d8 inbred 14 both 10-18wks N=7
    Brown2 22552 visual water box (none) visual discrimination, pattern discrimination, percent correct performance, 0.17 grating threshold, day 8   [%]  pct_pat_disc_d8 inbred 14 both 10-18wks N=7
    Brown2 22553 visual water box (none) percent correct   [%]     grating threshold:    0.17 (low)    0.32    0.64 (high) inbred 14 both 10-18wks N=7
    Brown2 22555 visual water box (none) visual discrimination, detection mean latency to reach cued platform, day 8   [s]  vis_detec_ave_d8 inbred 14 both 10-18wks N=7
    Brown2 22556 visual water box (none) visual discrimination, pattern discrimination mean latency to reach cued platform, day 8   [s]  pat_disc_ave_d8 inbred 14 both 10-18wks N=7
    Brown2 22557 visual water box (none) latency to reach cued platform   [s]     grating threshold:    0.17 (low)    0.32    0.64 (high)    overall mean inbred 14 both 10-18wks N=7
    Brown2 22561 rotarod (none) latency to fall from accelerating (8 rpm/min) rotarod   [s]     day1    day2    day3    day4    day5    day6    day7 inbred 12 both 10-18wks N=12
    Brown2 22570 olfactory discrimination task (none) percent digging pooled across training conditions (Lemon CS+ plus Rose CS+)   [%]  CS+dig_pct_pooled inbred 13 both 10-18wks N=11
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