MPD: Project measures / variables set: Berndt2 airway

Project measures / variables set: Berndt2 airway_elas

ID, description, units	MPD:35191 airway_elas lung tissue dynamic elastance (H₂0 pressure) [cm/mL] methacholine study
Measures	• saline • 1 MCh • 3 MCh • 10 MCh • 30 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	ventilator
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001942 lung capacity VT:0002314 respiratory mechanics trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic MP:0011043 abnormal lung elastance

Values Means Δ Means Z-scores

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Berndt2 - lung tissue dynamic elastance (H₂0 pressure)

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	33211.6552	33211.6552	70.8765	< 0.0001
between strain	23	143627.8166	6244.6877	13.3267	< 0.0001
between sex:strain	23	32354.1322	1406.7014	3.002	< 0.0001
between Residuals	251	117614.8551	468.5851
within group	4	269251.8537	67312.9634	648.1558	< 0.0001
within group:sex	4	238.5683	59.6421	0.5743	0.6813
within group:strain	92	31342.7553	340.6821	3.2804	< 0.0001
within group:sex:strain	92	26692.6337	290.1373	2.7937	< 0.0001
within Residuals	1004	104268.4689	103.8531

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35191	ventilator	methacholine	lung tissue dynamic elastance (H₂0 pressure) [cm/mL] saline airway_elas_saline	inbred	29	both	9-12wks
Berndt2	35192	ventilator	methacholine	lung tissue dynamic elastance (H₂0 pressure) [cm/mL] 1 MCh airway_elas_mch1	inbred	29	both	9-12wks
Berndt2	35193	ventilator	methacholine	lung tissue dynamic elastance (H₂0 pressure) [cm/mL] 3 MCh airway_elas_mch3	inbred	29	both	9-12wks
Berndt2	35194	ventilator	methacholine	lung tissue dynamic elastance (H₂0 pressure) [cm/mL] 10 MCh airway_elas_mch10	inbred	29	both	9-12wks
Berndt2	35195	ventilator	methacholine	lung tissue dynamic elastance (H₂0 pressure) [cm/mL] 30 MCh airway_elas_mch30	inbred	29	both	9-12wks
Berndt2	35196	ventilator	methacholine	lung tissue dynamic elastance (H₂0 pressure) [cm/mL] response index airway_elas_slope	inbred	29	both	9-12wks	(supplemental / summary measure)