Maurer1: Drug study: Cardiovascular response to beta-adrenergic blockade or activation in males of 23 inbred strains of mice (2009)

Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Abriel H, Pedrazzini T, Beckmann JS, Bergmann S, Maurer F. Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. PLoS One. 2009 Aug 12;4(8):e6610.   PubMed 19672458     FullText


       
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Participants Fabienne Maurer       University of Lausanne Lausanne SWITZERLAND
Jacques Beckmann       University of Lausanne Lausanne SWITZERLAND
Hugues Abriel       University of Lausanne Lausanne SWITZERLAND
Thierry Pedrazzini       University of Lausanne Lausanne SWITZERLAND
With: Berthonneche C, Peter B, Schüpfer F, Hayoz P, Kutalik Z, Bergmann S,
ContactFabienne Maurer     fabienne.maurer@chuv.ch     Lab web site
AcknowledgementsFunding provided by Centre Hospitalier Universitaire Vaudois, University of Lausanne, Swiss National Science Foundation, Giorgi-Cavaglieri Foundation
Project type Phenotype strain survey data set
MPD identifiersMaurer1     MPD:332
Data changelog No updates/corrections.       Initial release date: 03/2010.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation of the cardiovascular effect of a β-adrenergic receptor blocker and a β-agonist in four treatment group cohorts: (1) Control; (2) Treated with 10 mg/kg/day atenolol for 2 wks; (3) Treated with 1 mg/kg/day isoproterenol for 2 wks; (4) Treated with 10 mg/kg/day isoproterenol for 2 wks.

Summary of procedures that were conducted
• body weight Isoproterenol or atenolol vs. control.
• organ weights Heart, atria, ventricle weights. Isoproterenol or atenolol vs. control.
• tail cuff Heart rate and blood pressure. Conscious mice. Isoproterenol or atenolol vs. control.
• ECG Heart rate and wave amplitudes and intervals. Conscious. Isoproterenol or atenolol vs. control.
Mice: inbred   23 strains   ♂   age 10-12wks   4 cohorts

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Maurer1 33201 tail cuff atenolol, isoproterenol pulse rate   [n/min]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33205 ECG atenolol, isoproterenol heart rate   [n/min]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33209 tail cuff atenolol, isoproterenol systolic blood pressure   [mmHg]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33213 ECG atenolol, isoproterenol amplitude of P-wave   [mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33217 ECG atenolol, isoproterenol amplitude of Q-wave   [mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=9
    Maurer1 33221 ECG atenolol, isoproterenol amplitude of R-wave   [mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=9
    Maurer1 33225 ECG atenolol, isoproterenol amplitude of S-wave   [mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=9
    Maurer1 33229 ECG atenolol, isoproterenol duration P-wave   [ms]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33233 ECG atenolol, isoproterenol interval PR   [ms]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33237 ECG atenolol, isoproterenol interval RR   [ms]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33241 ECG atenolol, isoproterenol interval QRS   [ms]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33245 ECG atenolol, isoproterenol interval QT   [ms]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33249 ECG atenolol, isoproterenol interval ST   [ms]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33253 ECG atenolol, isoproterenol area of P-wave   [ms*mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=9
    Maurer1 33257 ECG atenolol, isoproterenol area of QRS   [ms*mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=9
    Maurer1 33261 ECG atenolol, isoproterenol area of QTc   [ms*mV]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33265 body weight (none) body weight at start of testing, all cohorts combined   [g]  bw_start inbred 23 m 7-13wks N=41
    Maurer1 33266 body weight atenolol, isoproterenol fold change in body weight over testing period   [ratio]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33270 organ weights atenolol, isoproterenol heart weight   [mg]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33274 organ weights atenolol, isoproterenol heart weight normalized to body weight   [mg/g]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33278 organ weights atenolol, isoproterenol atria weight   [mg]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33282 organ weights atenolol, isoproterenol atria weight normalized to body weight   [mg/g]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33286 organ weights atenolol, isoproterenol ventricle (both) weight   [mg]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33290 organ weights atenolol, isoproterenol ventricle (both) weight normalized to body weight   [mg/g]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
    Maurer1 33294 organ weights atenolol, isoproterenol atria weight to ventricle weight ratio   [ratio]     control    atenolol 10mg    isoprot 1mg    isoprot 10mg inbred 23 m 7-13wks N=10
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