Project measure / variable:   Paigen2   CHOL

ID, description, units MPD:9906   CHOL   total cholesterol (plasma)   [mg/dL]  baseline  
high-fat diet study
Data set, strains Paigen2   inbred w/CC7   42 strains     sex: both     age: 7-9wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen2 - total cholesterol (plasma) baseline



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested40 strains41 strains
Mean of the strain means86.5   mg/dL 102   mg/dL
Median of the strain means79.7   mg/dL 95.9   mg/dL
SD of the strain means± 27.9 ± 25.5
Coefficient of variation (CV)0.323 0.249
Min–max range of strain means45.0   –   187   mg/dL 55.4   –   155   mg/dL
Mean sample size per strain10.2   mice 12.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 50077.8162 50077.8162 140.0487 < 0.0001
strain 38 522807.8011 13758.1 38.4762 < 0.0001
sex:strain 38 58885.708 1549.6239 4.3337 < 0.0001
Residuals 810 289635.2591 357.5744


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 110.0 20.7   10 6.55 0.189 79.0, 132.0 0.84
129S1/SvImJ m 142.0 21.7   9 7.24 0.153 106.0, 170.0 1.55
A/J f 68.8 7.25   11 2.19 0.105 54.0, 77.0 -0.63
A/J m 77.9 12.1   23 2.52 0.155 62.0, 111.0 -0.96
AKR/J f 74.3 10.5   14 2.8 0.141 56.0, 90.0 -0.44
AKR/J m 78.3 11.7   9 3.89 0.149 65.0, 97.0 -0.95
BALB/cByJ f 78.7 21.8   12 6.29 0.277 47.0, 113.0 -0.28
BALB/cByJ m 92.6 16.2   22 3.45 0.175 57.0, 122.0 -0.39
BTBR T+ Itpr3tf/J f 95.4 10.9   8 3.85 0.114 77.0, 109.0 0.32
BTBR T+ Itpr3tf/J m 104.0 9.78   7 3.7 0.0944 89.0, 119.0 0.06
BUB/BnJ f 59.2 8.94   11 2.7 0.151 45.0, 71.0 -0.98
BUB/BnJ m 84.6 18.8   5 8.4 0.222 57.0, 102.0 -0.7
C3H/HeJ f 101.0 29.5   10 9.34 0.292 67.0, 178.0 0.52
C3H/HeJ m 131.0 19.8   26 3.88 0.151 107.0, 179.0 1.12
C57BL/10J f 73.8 13.9   10 4.38 0.188 56.0, 101.0 -0.45
C57BL/10J m 95.9 21.3   15 5.5 0.222 59.0, 138.0 -0.26
C57BL/6J f 83.1 21.2   10 6.7 0.255 61.0, 125.0 -0.12
C57BL/6J m 117.0 23.3   10 7.36 0.199 79.0, 153.0 0.57
C57BLKS/J f 66.5 33.7   10 10.7 0.507 42.0, 159.0 -0.72
C57BR/cdJ f 89.2 10.6   10 3.36 0.119 77.0, 110.0 0.1
C57BR/cdJ m 81.5 8.16   12 2.36 0.1 71.0, 98.0 -0.82
C57L/J f 72.8 12.3   10 3.88 0.169 57.0, 94.0 -0.49
C57L/J m 71.3 9.44   10 2.99 0.132 57.0, 87.0 -1.22
C58/J f 92.8 6.02   5 2.69 0.0648 84.0, 101.0 0.23
C58/J m 90.5 48.0   11 14.5 0.53 36.0, 209.0 -0.47
CAST/EiJ f 65.7 12.7   9 4.23 0.193 51.0, 92.0 -0.74
CAST/EiJ m 76.5 8.15   10 2.58 0.107 56.0, 85.0 -1.02
CBA/J f 66.1 5.33   8 1.88 0.0806 58.0, 72.0 -0.73
CBA/J m 122.0 29.5   10 9.34 0.243 86.0, 184.0 0.77
CE/J m 113.0 16.9   9 5.63 0.149 89.0, 135.0 0.41
CZECHII/EiJ f 72.0 8.92   18 2.1 0.124 56.0, 84.0 -0.52
CZECHII/EiJ m 77.7 24.6   13 6.84 0.317 37.0, 132.0 -0.97
DBA/1J f 54.1 32.3   9 10.8 0.596 27.0, 136.0 -1.16
DBA/1J m 82.7 27.2   10 8.61 0.329 44.0, 125.0 -0.78
DBA/2J f 79.8 11.1   10 3.52 0.14 70.0, 103.0 -0.24
DBA/2J m 128.0 21.4   10 6.78 0.167 94.0, 157.0 1.0
FVB/NJ f 145.0 15.3   11 4.61 0.105 120.0, 169.0 2.1
FVB/NJ m 139.0 9.41   10 2.98 0.0678 128.0, 155.0 1.43
I/LnJ f 55.8 8.38   10 2.65 0.15 43.0, 74.0 -1.1
I/LnJ m 84.1 13.8   10 4.37 0.164 68.0, 112.0 -0.72
JF1/MsJ f 88.3 12.8   10 4.06 0.145 69.0, 110.0 0.07
JF1/MsJ m 89.8 18.2   14 4.87 0.203 57.0, 113.0 -0.5
KK/HlJ f 187.0 51.7   7 19.5 0.277 139.0, 296.0 3.6
KK/HlJ m 155.0 35.6   5 15.9 0.23 121.0, 198.0 2.06
LP/J f 88.8 20.3   11 6.13 0.229 66.0, 130.0 0.08
LP/J m 106.0 37.3   12 10.8 0.353 72.0, 193.0 0.14
MA/MyJ f 117.0 10.4   10 3.28 0.0889 103.0, 140.0 1.09
MA/MyJ m 142.0 9.57   10 3.03 0.0675 125.0, 158.0 1.55
MOLF/EiJ f 92.0 17.9   7 6.75 0.194 77.0, 127.0 0.2
MOLF/EiJ m 86.9 12.8   13 3.54 0.147 71.0, 113.0 -0.61
MSM/MsJ f 90.5 10.4   8 3.67 0.115 73.0, 104.0 0.14
MSM/MsJ m 85.5 9.45   14 2.53 0.111 73.0, 103.0 -0.67
NOD/ShiLtJ f 78.6 10.2   16 2.54 0.129 60.0, 92.0 -0.28
NOD/ShiLtJ m 106.0 16.3   12 4.7 0.154 84.0, 131.0 0.14
NON/ShiLtJ f 85.4 14.7   10 4.66 0.172 47.0, 98.0 -0.04
NON/ShiLtJ m 136.0 19.5   20 4.36 0.144 106.0, 196.0 1.32
NZB/BlNJ f 143.0 20.0   14 5.35 0.14 106.0, 177.0 2.03
NZB/BlNJ m 144.0 16.4   10 5.2 0.114 120.0, 179.0 1.63
NZW/LacJ f 109.0 10.2   10 3.21 0.0934 83.0, 117.0 0.81
NZW/LacJ m 136.0 27.1   8 9.6 0.2 100.0, 185.0 1.32
PERA/EiJ f 56.4 25.8   9 8.59 0.456 32.0, 116.0 -1.08
PERA/EiJ m 55.4 16.6   9 5.52 0.299 37.0, 89.0 -1.85
PL/J f 90.6 14.0   11 4.21 0.154 73.0, 119.0 0.15
PL/J m 110.0 18.2   11 5.49 0.166 94.0, 153.0 0.3
PWK/PhJ m 74.2 11.9   16 2.97 0.16 58.0, 96.0 -1.11
RF/J f 96.7 26.2   12 7.58 0.272 56.0, 130.0 0.37
RF/J m 121.0 22.2   17 5.39 0.183 84.0, 170.0 0.73
RIIIS/J f 45.0 8.43   10 2.67 0.187 33.0, 56.0 -1.49
RIIIS/J m 58.7 8.32   22 1.77 0.142 44.0, 72.0 -1.72
SEA/GnJ f 72.5 8.73   10 2.76 0.12 57.0, 87.0 -0.5
SEA/GnJ m 85.3 11.5   7 4.36 0.135 69.0, 105.0 -0.67
SJL/J f 79.5 19.0   10 6.02 0.239 57.0, 122.0 -0.25
SJL/J m 95.5 18.4   15 4.75 0.193 71.0, 132.0 -0.27
SM/J f 63.0 5.61   9 1.87 0.0891 57.0, 72.0 -0.84
SM/J m 91.6 17.8   17 4.32 0.194 70.0, 139.0 -0.43
SPRET/EiJ f 131.0 21.7   11 6.55 0.166 94.0, 160.0 1.6
SPRET/EiJ m 132.0 19.4   13 5.39 0.147 93.0, 163.0 1.16
SWR/J f 72.0 14.5   12 4.18 0.201 54.0, 100.0 -0.52
SWR/J m 99.0 12.0   12 3.47 0.121 84.0, 123.0 -0.14
WSB/EiJ f 68.2 26.6   8 9.4 0.39 9.0, 94.0 -0.65
WSB/EiJ m 102.0 28.8   14 7.71 0.283 27.0, 144.0 -0.02


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 109.8 5.9798 121.5376 98.0624
129S1/SvImJ m 142.2222 6.3032 154.5948 129.8497
A/J f 68.8182 5.7015 80.0096 57.6268
A/J m 77.8696 3.9429 85.6091 70.13
AKR/J f 74.2857 5.0538 84.2058 64.3656
AKR/J m 78.3333 6.3032 90.7059 65.9608
BALB/cByJ f 78.6667 5.4587 89.3816 67.9517
BALB/cByJ m 92.5909 4.0315 100.5044 84.6774
BTBR T+ Itpr3tf/J f 95.375 6.6856 108.4981 82.2519
BTBR T+ Itpr3tf/J m 103.5714 7.1472 117.6006 89.5423
BUB/BnJ f 59.1818 5.7015 70.3732 47.9904
BUB/BnJ m 84.6 8.4566 101.1995 68.0005
C3H/HeJ f 101.1 5.9798 112.8376 89.3624
C3H/HeJ m 131.2308 3.7085 138.5101 123.9514
C57BL/10J f 73.8 5.9798 85.5376 62.0624
C57BL/10J m 95.9333 4.8824 105.5171 86.3496
C57BL/6J f 83.1 5.9798 94.8376 71.3624
C57BL/6J m 117.0 5.9798 128.7376 105.2624
C57BR/cdJ f 89.2 5.9798 100.9376 77.4624
C57BR/cdJ m 81.5 5.4587 92.2149 70.7851
C57L/J f 72.8 5.9798 84.5376 61.0624
C57L/J m 71.3 5.9798 83.0376 59.5624
C58/J f 92.8 8.4566 109.3995 76.2005
C58/J m 90.5455 5.7015 101.7369 79.3541
CAST/EiJ f 65.6667 6.3032 78.0392 53.2941
CAST/EiJ m 76.5 5.9798 88.2376 64.7624
CBA/J f 66.125 6.6856 79.2481 53.0019
CBA/J m 121.5 5.9798 133.2376 109.7624
CZECHII/EiJ f 72.0 4.457 80.7487 63.2513
CZECHII/EiJ m 77.6923 5.2446 87.9869 67.3977
DBA/1J f 54.1111 6.3032 66.4837 41.7386
DBA/1J m 82.7 5.9798 94.4376 70.9624
DBA/2J f 79.8 5.9798 91.5376 68.0624
DBA/2J m 128.1 5.9798 139.8376 116.3624
FVB/NJ f 144.9091 5.7015 156.1005 133.7177
FVB/NJ m 138.8 5.9798 150.5376 127.0624
I/LnJ f 55.8 5.9798 67.5376 44.0624
I/LnJ m 84.1 5.9798 95.8376 72.3624
JF1/MsJ f 88.3 5.9798 100.0376 76.5624
JF1/MsJ m 89.7857 5.0538 99.7058 79.8656
KK/HlJ f 186.7143 7.1472 200.7434 172.6851
KK/HlJ m 154.6 8.4566 171.1995 138.0005
LP/J f 88.8182 5.7015 100.0096 77.6268
LP/J m 105.6667 5.4587 116.3816 94.9517
MA/MyJ f 116.7 5.9798 128.4376 104.9624
MA/MyJ m 141.9 5.9798 153.6376 130.1624
MOLF/EiJ f 92.0 7.1472 106.0292 77.9708
MOLF/EiJ m 86.9231 5.2446 97.2177 76.6285
MSM/MsJ f 90.5 6.6856 103.6231 77.3769
MSM/MsJ m 85.5 5.0538 95.4201 75.5799
NOD/ShiLtJ f 78.5625 4.7274 87.8419 69.2831
NOD/ShiLtJ m 105.8333 5.4587 116.5483 95.1184
NON/ShiLtJ f 85.4 5.9798 97.1376 73.6624
NON/ShiLtJ m 135.85 4.2283 144.1498 127.5502
NZB/BlNJ f 143.1429 5.0538 153.063 133.2227
NZB/BlNJ m 144.2 5.9798 155.9376 132.4624
NZW/LacJ f 108.8 5.9798 120.5376 97.0624
NZW/LacJ m 135.75 6.6856 148.8731 122.6269
PERA/EiJ f 56.4444 6.3032 68.817 44.0719
PERA/EiJ m 55.4444 6.3032 67.817 43.0719
PL/J f 90.6364 5.7015 101.8278 79.445
PL/J m 109.5455 5.7015 120.7369 98.3541
RF/J f 96.6667 5.4587 107.3816 85.9517
RF/J m 121.4118 4.5863 130.4141 112.4094
RIIIS/J f 45.0 5.9798 56.7376 33.2624
RIIIS/J m 58.6818 4.0315 66.5953 50.7683
SEA/GnJ f 72.5 5.9798 84.2376 60.7624
SEA/GnJ m 85.2857 7.1472 99.3149 71.2566
SJL/J f 79.5 5.9798 91.2376 67.7624
SJL/J m 95.4667 4.8824 105.0504 85.8829
SM/J f 63.0 6.3032 75.3726 50.6274
SM/J m 91.6471 4.5863 100.6494 82.6447
SPRET/EiJ f 131.0909 5.7015 142.2823 119.8995
SPRET/EiJ m 131.7692 5.2446 142.0638 121.4746
SWR/J f 72.0 5.4587 82.7149 61.2851
SWR/J m 99.0 5.4587 109.7149 88.2851
WSB/EiJ f 68.25 6.6856 81.3731 55.1269
WSB/EiJ m 101.7143 5.0538 111.6344 91.7942


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 126.0111 4.3442 134.5383 117.4839
A/J both 73.3439 3.466 80.1473 66.5404
AKR/J both 76.3095 4.0395 84.2387 68.3803
BALB/cByJ both 85.6288 3.3931 92.289 78.9686
BTBR T+ Itpr3tf/J both 99.4732 4.8933 109.0783 89.8681
BUB/BnJ both 71.8909 5.0996 81.9008 61.881
C3H/HeJ both 116.1654 3.5182 123.0712 109.2596
C57BL/10J both 84.8667 3.8599 92.4433 77.2901
C57BL/6J both 100.05 4.2283 108.3498 91.7502
C57BR/cdJ both 85.35 4.0483 93.2964 77.4036
C57L/J both 72.05 4.2283 80.3498 63.7502
C58/J both 91.6727 5.0996 101.6826 81.6628
CAST/EiJ both 71.0833 4.3442 79.6105 62.5561
CBA/J both 93.8125 4.4848 102.6157 85.0093
CZECHII/EiJ both 74.8462 3.4413 81.6011 68.0912
DBA/1J both 68.4056 4.3442 76.9328 59.8784
DBA/2J both 103.95 4.2283 112.2498 95.6502
FVB/NJ both 141.8545 4.1311 149.9635 133.7456
I/LnJ both 69.95 4.2283 78.2498 61.6502
JF1/MsJ both 89.0429 3.9147 96.7269 81.3588
KK/HlJ both 170.6571 5.5362 181.5241 159.7902
LP/J both 97.2424 3.9467 104.9893 89.4955
MA/MyJ both 129.3 4.2283 137.5998 121.0002
MOLF/EiJ both 89.4615 4.4325 98.1621 80.761
MSM/MsJ both 88.0 4.1904 96.2253 79.7747
NOD/ShiLtJ both 92.1979 3.6106 99.2852 85.1106
NON/ShiLtJ both 110.625 3.6618 117.8128 103.4372
NZB/BlNJ both 143.6714 3.9147 151.3555 135.9873
NZW/LacJ both 122.275 4.4848 131.0782 113.4718
PERA/EiJ both 55.9444 4.457 64.6932 47.1957
PL/J both 100.0909 4.0315 108.0044 92.1774
RF/J both 109.0392 3.5648 116.0366 102.0418
RIIIS/J both 51.8409 3.6059 58.919 44.7628
SEA/GnJ both 78.8929 4.6594 88.0388 69.747
SJL/J both 87.4833 3.8599 95.0599 79.9067
SM/J both 77.3235 3.8976 84.9741 69.673
SPRET/EiJ both 131.4301 3.8734 139.0331 123.827
SWR/J both 85.5 3.8599 93.0766 77.9234
WSB/EiJ both 84.9821 4.1904 93.2075 76.7568




  GWAS USING LINEAR MIXED MODELS