Project measure / variable:   Mogil3   baseline

ID, description, units MPD:48001   baseline   50% hindpaw withdrawal threshold, von Frey test   [g]  
Data set, strains Mogil3   inbred   18 strains     sex: both     age: 7-12wks
Procedure nociception assay
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  STRAIN COMPARISON PLOT
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Mogil3 - 50% hindpaw withdrawal threshold, von Frey test



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested18 strains18 strains
Mean of the strain means0.348   g 0.407   g
Median of the strain means0.352   g 0.387   g
SD of the strain means± 0.168 ± 0.244
Coefficient of variation (CV)0.484 0.598
Min–max range of strain means0.110   –   0.717   g 0.100   –   1.09   g
Mean sample size per strain2.9   mice 2.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.1061 0.1061 4.5837 0.0361
strain 17 3.2711 0.1924 8.3108 < 0.0001
sex:strain 17 0.9743 0.0573 2.4755 0.0047
Residuals 64 1.4818 0.0232


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.13 0.0608   3 0.0351 0.468 0.09, 0.2 -1.3
129S1/SvImJ m 0.155 0.00707   2   0.005 0.0456 0.15, 0.16 -1.03
A/HeJ f 0.36 0.0693   3 0.04 0.192 0.28, 0.4 0.07
A/HeJ m 0.455 0.233   2   0.165 0.513 0.29, 0.62 0.2
A/J f 0.413 0.165   3 0.0953 0.399 0.25, 0.58 0.39
A/J m 0.393 0.188   3 0.108 0.477 0.28, 0.61 -0.06
AKR/J f 0.357 0.116   3 0.0669 0.325 0.25, 0.48 0.05
AKR/J m 0.287 0.0451   3 0.026 0.157 0.24, 0.33 -0.49
B10.D2-Hc0 f 0.48 0.348   3 0.201 0.726 0.2, 0.87 0.78
B10.D2-Hc0 m 1.09 0.251   3 0.145 0.23 0.94, 1.38 2.8
BALB/cByJ f 0.347 0.122   3 0.0706 0.353 0.24, 0.48 -0.01
BALB/cByJ m 0.697 0.262   3 0.151 0.375 0.42, 0.94 1.19
BALB/cJ f 0.33 0.198   2   0.14 0.6 0.19, 0.47 -0.11
BALB/cJ m 0.31 0.0566   2   0.04 0.182 0.27, 0.35 -0.4
BUB/BnJ f 0.677 0.103   3 0.0593 0.152 0.59, 0.79 1.95
BUB/BnJ m 0.743 0.202   3 0.117 0.272 0.56, 0.96 1.38
C3H/HeJ f 0.473 0.0586   3 0.0338 0.124 0.43, 0.54 0.74
C3H/HeJ m 0.54 0.0283   2   0.02 0.0524 0.52, 0.56 0.55
C57BL/6J f 0.237 0.0153   3 0.00882 0.0645 0.22, 0.25 -0.66
C57BL/6J m 0.26 0.0656   3 0.0379 0.252 0.19, 0.32 -0.6
DBA/2J f 0.177 0.0577   3 0.0333 0.327 0.11, 0.21 -1.02
DBA/2J m 0.137 0.0252   3 0.0145 0.184 0.11, 0.16 -1.11
FVB/NJ f 0.165 0.0212   2   0.015 0.129 0.15, 0.18 -1.09
FVB/NJ m 0.1 0.0283   2   0.02 0.283 0.08, 0.12 -1.26
LG/J f 0.223 0.00577   3 0.00333 0.0259 0.22, 0.23 -0.74
LG/J m 0.24 0.0656   3 0.0379 0.273 0.18, 0.31 -0.69
LP/J f 0.303 0.15   3 0.0869 0.496 0.13, 0.4 -0.27
LP/J m 0.457 0.286   3 0.165 0.626 0.16, 0.73 0.21
MRL/MpJ f 0.37 0.127   2   0.09 0.344 0.28, 0.46 0.13
MRL/MpJ m 0.273 0.0874   3 0.0504 0.32 0.2, 0.37 -0.55
NZB/BlNJ f 0.717 0.249   3 0.144 0.348 0.53, 1.0 2.19
NZB/BlNJ m 0.41 0.0557   3 0.0321 0.136 0.35, 0.46 0.01
NZW/LacJ f 0.11 0.0361   3 0.0208 0.328 0.07, 0.14 -1.41
NZW/LacJ m 0.38 0.125   3 0.0721 0.329 0.28, 0.52 -0.11
SM/J f 0.397 0.0473   3 0.0273 0.119 0.36, 0.45 0.29
SM/J m 0.4 0.255   3 0.147 0.638 0.21, 0.69 -0.03


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.13 0.0878 0.3055 0.0
129S1/SvImJ m 0.155 0.1076 0.3699 0.0
A/HeJ f 0.36 0.0878 0.5355 0.1845
A/HeJ m 0.455 0.1076 0.6699 0.2401
A/J f 0.4133 0.0878 0.5888 0.2378
A/J m 0.3933 0.0878 0.5688 0.2178
AKR/J f 0.3567 0.0878 0.5322 0.1812
AKR/J m 0.2867 0.0878 0.4622 0.1112
B10.D2-Hc0 f 0.48 0.0878 0.6555 0.3045
B10.D2-Hc0 m 1.09 0.0878 1.2655 0.9145
BALB/cByJ f 0.3467 0.0878 0.5222 0.1712
BALB/cByJ m 0.6967 0.0878 0.8722 0.5212
BALB/cJ f 0.33 0.1076 0.5449 0.1151
BALB/cJ m 0.31 0.1076 0.5249 0.0951
BUB/BnJ f 0.6767 0.0878 0.8522 0.5012
BUB/BnJ m 0.7433 0.0878 0.9188 0.5678
C3H/HeJ f 0.4733 0.0878 0.6488 0.2978
C3H/HeJ m 0.54 0.1076 0.7549 0.3251
C57BL/6J f 0.2367 0.0878 0.4122 0.0612
C57BL/6J m 0.26 0.0878 0.4355 0.0845
DBA/2J f 0.1767 0.0878 0.3522 0.0012
DBA/2J m 0.1367 0.0878 0.3122 0.0
FVB/NJ f 0.165 0.1076 0.3799 0.0
FVB/NJ m 0.1 0.1076 0.3149 0.0
LG/J f 0.2233 0.0878 0.3988 0.0478
LG/J m 0.24 0.0878 0.4155 0.0645
LP/J f 0.3033 0.0878 0.4788 0.1278
LP/J m 0.4567 0.0878 0.6322 0.2812
MRL/MpJ f 0.37 0.1076 0.5849 0.1551
MRL/MpJ m 0.2733 0.0878 0.4488 0.0978
NZB/BlNJ f 0.7167 0.0878 0.8922 0.5412
NZB/BlNJ m 0.41 0.0878 0.5855 0.2345
NZW/LacJ f 0.11 0.0878 0.2855 0.0
NZW/LacJ m 0.38 0.0878 0.5555 0.2045
SM/J f 0.3967 0.0878 0.5722 0.2212
SM/J m 0.4 0.0878 0.5755 0.2245


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.1425 0.0695 0.2812 0.0038
A/HeJ both 0.4075 0.0695 0.5462 0.2688
A/J both 0.4033 0.0621 0.5274 0.2792
AKR/J both 0.3217 0.0621 0.4458 0.1976
B10.D2-Hc0 both 0.785 0.0621 0.9091 0.6609
BALB/cByJ both 0.5217 0.0621 0.6458 0.3976
BALB/cJ both 0.32 0.0761 0.472 0.168
BUB/BnJ both 0.71 0.0621 0.8341 0.5859
C3H/HeJ both 0.5067 0.0695 0.6454 0.3679
C57BL/6J both 0.2483 0.0621 0.3724 0.1242
DBA/2J both 0.1567 0.0621 0.2808 0.0326
FVB/NJ both 0.1325 0.0761 0.2845 0.0
LG/J both 0.2317 0.0621 0.3558 0.1076
LP/J both 0.38 0.0621 0.5041 0.2559
MRL/MpJ both 0.3217 0.0695 0.4604 0.1829
NZB/BlNJ both 0.5633 0.0621 0.6874 0.4392
NZW/LacJ both 0.245 0.0621 0.3691 0.1209
SM/J both 0.3983 0.0621 0.5224 0.2742




  GWAS USING LINEAR MIXED MODELS