Mogil3: Spared nerve injury induced mechanical allodynia in 18 inbred strains of mice (2012)

Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012 Mar 25;18(4):595-9. doi: 10.1038/nm.2710.   PubMed 22447075     FullText


       
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Participants Jeffrey S Mogil       McGill University Montreal, Quebec CANADA
Michael W Salter       University of Toronto Toronto CANADA
With: Sorge RE, Trang T
ContactJeffrey S Mogil     jeffrey.mogil@mcgill.ca     Lab web site
AcknowledgementsFunding provided by National Institutes of Health, Louise and Alan Edwards Foundation, Canada Research Chairs program, Howard Hughes Medical Institute, Canadian Institutes of Health Research, Krembil Foundation, Ontario Research Foundation, Algynomics/Pfizer, AstraZeneca–Alan Edwards Centre for Research on Pain, Canadian Institutes of Health
Project type Phenotype strain survey data set
MPD identifiersMogil3     MPD:480
Data changelog No updates/corrections.       Initial release date: 06/2013.
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Summary of procedures that were conducted
• nociception assay von Frey nociception test, baseline and after spared nerve injury (SNI) surgery as a hypersensitizer.
Mice: inbred   18 strains   ♀♂   age 7-12wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Mogil3 48001 nociception assay (none) 50% hindpaw withdrawal threshold, von Frey test   [g]  baseline inbred 18 both 7-12wks N=3
    Mogil3 48002 nociception assay (none) percentage of maximum hindpaw mechanical allodynia
over 28 days after spared nerve injury   [%]
 allodynia
inbred 18 both 7-12wks N=3
    All boxes