Project measure / variable:   Berndt2   exp_flow_slope

ID, description, units MPD:35152   exp_flow_slope   expiratory flow rate   [mL/kg/s]  response index  
methacholine study
Data set, strains Berndt2   inbred   29 strains     sex: both     age: 9-12wks
Procedure plethysmography
Ontology mappings

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  STRAIN COMPARISON PLOT
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Berndt2 - expiratory flow rate response index



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested29 strains29 strains
Mean of the strain means0.212   mL/kg/s 0.248   mL/kg/s
Median of the strain means0.194   mL/kg/s 0.241   mL/kg/s
SD of the strain means± 0.242 ± 0.243
Coefficient of variation (CV)1.14 0.979
Min–max range of strain means-0.261   –   0.685   mL/kg/s -0.217   –   0.634   mL/kg/s
Mean sample size per strain8.0   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.1801 0.1801 2.2471 0.1346
strain 28 23.8248 0.8509 10.6169 < 0.0001
sex:strain 28 3.3496 0.1196 1.4927 0.0532
Residuals 412 33.0195 0.0801


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.661 0.392   8 0.139 0.593 -0.028, 1.06 1.85
129S1/SvImJ m 0.589 0.357   8 0.126 0.606 0.125, 1.05 1.4
A/J f -0.207 0.164   8 0.058 -0.794 -0.4, 0.039 -1.73
A/J m -0.214 0.14   8 0.0496 -0.657 -0.394, 0.026 -1.9
AKR/J f 0.203 0.155   8 0.0547 0.76 -0.002, 0.525 -0.04
AKR/J m 0.597 0.268   8 0.0946 0.448 0.129, 0.962 1.43
BALB/cByJ f 0.179 0.216   8 0.0762 1.2 -0.104, 0.584 -0.14
BALB/cByJ m 0.211 0.139   8 0.049 0.657 0.04, 0.412 -0.15
BALB/cJ f 0.0701 0.136   10 0.043 1.94 -0.191, 0.277 -0.59
BALB/cJ m 0.103 0.195   10 0.0616 1.89 -0.319, 0.347 -0.6
BTBR T+ Itpr3tf/J f 0.0702 0.354   8 0.125 5.04 -0.339, 0.813 -0.59
BTBR T+ Itpr3tf/J m -0.217 0.16   8 0.0566 -0.738 -0.416, 0.065 -1.91
BUB/BnJ f 0.227 0.294   7 0.111 1.3 -0.094, 0.747 0.06
BUB/BnJ m 0.257 0.313   8 0.111 1.22 -0.128, 0.606 0.04
C3H/HeJ f 0.152 0.333   8 0.118 2.19 -0.29, 0.509 -0.25
C3H/HeJ m 0.104 0.337   8 0.119 3.23 -0.338, 0.642 -0.59
C57BL/10J f 0.367 0.187   8 0.0662 0.509 0.118, 0.624 0.64
C57BL/10J m 0.35 0.134   7 0.0505 0.382 0.129, 0.543 0.42
C57BL/6J f 0.509 0.27   7 0.102 0.529 0.133, 0.862 1.22
C57BL/6J m 0.634 0.283   13 0.0786 0.447 0.331, 1.08 1.59
C57BLKS/J f 0.482 0.369   11 0.111 0.766 -0.149, 1.05 1.11
C57BLKS/J m 0.567 0.31   8 0.11 0.546 0.156, 1.07 1.31
C57BR/cdJ f 0.414 0.479   6 0.196 1.16 -0.455, 0.825 0.83
C57BR/cdJ m 0.453 0.279   8 0.0986 0.616 -0.007, 0.797 0.84
C57L/J f 0.441 0.0592   8 0.0209 0.134 0.357, 0.534 0.94
C57L/J m 0.494 0.165   8 0.0583 0.334 0.153, 0.689 1.01
CBA/J f 0.551 0.154   8 0.0545 0.28 0.333, 0.802 1.4
CBA/J m 0.551 0.158   8 0.056 0.287 0.324, 0.731 1.24
CE/J f 0.194 0.394   8 0.139 2.03 -0.191, 1.05 -0.07
CE/J m 0.0699 0.162   9 0.0539 2.32 -0.13, 0.35 -0.73
DBA/1J f 0.271 0.193   10 0.0611 0.712 -0.054, 0.601 0.24
DBA/1J m -0.0181 0.177   8 0.0625 -9.76 -0.264, 0.211 -1.1
DBA/2J f 0.191 0.198   8 0.0701 1.04 -0.033, 0.542 -0.09
DBA/2J m 0.237 0.243   10 0.0769 1.03 0.051, 0.79 -0.05
FVB/NJ f 0.125 0.476   8 0.168 3.82 -0.595, 0.719 -0.36
FVB/NJ m 0.418 0.392   7 0.148 0.938 -0.142, 0.885 0.7
I/LnJ f 0.123 0.222   7 0.0839 1.8 -0.115, 0.472 -0.37
I/LnJ m 0.264 0.461   5 0.206 1.75 -0.36, 0.687 0.06
KK/HlJ f 0.416 0.188   8 0.0664 0.451 0.119, 0.643 0.84
KK/HlJ m 0.471 0.274   6 0.112 0.583 0.157, 0.957 0.92
LP/J f -0.101 0.458   8 0.162 -4.56 -1.02, 0.567 -1.29
LP/J m 0.241 0.29   8 0.103 1.21 -0.174, 0.825 -0.03
NOD/ShiLtJ f 0.685 0.254   8 0.0899 0.371 0.216, 1.02 1.95
NOD/ShiLtJ m 0.463 0.493   8 0.174 1.06 -0.482, 0.892 0.88
NON/ShiLtJ f -0.0432 0.276   8 0.0975 -6.38 -0.477, 0.438 -1.05
NON/ShiLtJ m -0.0171 0.237   8 0.0837 -13.8 -0.294, 0.482 -1.09
NZW/LacJ f 0.00613 0.143   8 0.0506 23.4 -0.237, 0.201 -0.85
NZW/LacJ m 0.092 0.207   8 0.0731 2.25 -0.263, 0.37 -0.64
PL/J f -0.261 0.284   8 0.101 -1.09 -0.631, 0.103 -1.95
PL/J m -0.0395 0.454   8 0.16 -11.5 -0.575, 0.789 -1.18
RIIIS/J f 0.273 0.133   8 0.047 0.487 0.073, 0.47 0.25
RIIIS/J m 0.0337 0.171   8 0.0606 5.08 -0.181, 0.297 -0.88
SJL/J f -0.0231 0.463   8 0.164 -20.0 -0.615, 0.562 -0.97
SJL/J m 0.0724 0.38   8 0.135 5.26 -0.471, 0.577 -0.72
SM/J f 0.201 0.226   8 0.0798 1.12 -0.072, 0.52 -0.05
SM/J m 0.164 0.337   8 0.119 2.06 -0.46, 0.647 -0.35
SWR/J f -0.0238 0.282   8 0.0997 -11.9 -0.379, 0.405 -0.97
SWR/J m 0.274 0.135   9 0.0451 0.494 0.052, 0.485 0.11


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.6606 0.1001 0.8574 0.4639
129S1/SvImJ m 0.5894 0.1001 0.7861 0.3926
A/J f -0.2069 0.1001 -0.0101 -0.4036
A/J m -0.2136 0.1001 -0.0169 -0.4104
AKR/J f 0.2034 0.1001 0.4001 0.0066
AKR/J m 0.5971 0.1001 0.7939 0.4004
BALB/cByJ f 0.1794 0.1001 0.3761 -0.0174
BALB/cByJ m 0.2109 0.1001 0.4076 0.0141
BALB/cJ f 0.0701 0.0895 0.2461 -0.1059
BALB/cJ m 0.1032 0.0895 0.2792 -0.0728
BTBR T+ Itpr3tf/J f 0.0703 0.1001 0.267 -0.1265
BTBR T+ Itpr3tf/J m -0.217 0.1001 -0.0202 -0.4138
BUB/BnJ f 0.2271 0.107 0.4375 0.0168
BUB/BnJ m 0.2575 0.1001 0.4543 0.0607
C3H/HeJ f 0.1517 0.1001 0.3485 -0.045
C3H/HeJ m 0.1044 0.1001 0.3011 -0.0924
C57BL/10J f 0.3675 0.1001 0.5643 0.1707
C57BL/10J m 0.3497 0.107 0.5601 0.1394
C57BL/6J f 0.5093 0.107 0.7196 0.2989
C57BL/6J m 0.6342 0.0785 0.7885 0.4798
C57BLKS/J f 0.4822 0.0854 0.65 0.3144
C57BLKS/J m 0.5673 0.1001 0.764 0.3705
C57BR/cdJ f 0.4137 0.1156 0.6409 0.1865
C57BR/cdJ m 0.4533 0.1001 0.65 0.2565
C57L/J f 0.4409 0.1001 0.6376 0.2441
C57L/J m 0.4945 0.1001 0.6913 0.2977
CBA/J f 0.5511 0.1001 0.7479 0.3544
CBA/J m 0.5515 0.1001 0.7483 0.3547
CE/J f 0.1938 0.1001 0.3905 -0.003
CE/J m 0.0699 0.0944 0.2554 -0.1156
DBA/1J f 0.2713 0.0895 0.4473 0.0953
DBA/1J m -0.0181 0.1001 0.1786 -0.2149
DBA/2J f 0.1907 0.1001 0.3875 -0.006
DBA/2J m 0.2367 0.0895 0.4127 0.0607
FVB/NJ f 0.1249 0.1001 0.3216 -0.0719
FVB/NJ m 0.4179 0.107 0.6282 0.2075
I/LnJ f 0.1233 0.107 0.3336 -0.0871
I/LnJ m 0.2636 0.1266 0.5125 0.0147
KK/HlJ f 0.4165 0.1001 0.6133 0.2197
KK/HlJ m 0.4708 0.1156 0.698 0.2436
LP/J f -0.1005 0.1001 0.0963 -0.2973
LP/J m 0.2406 0.1001 0.4374 0.0439
NOD/ShiLtJ f 0.6852 0.1001 0.882 0.4885
NOD/ShiLtJ m 0.463 0.1001 0.6598 0.2662
NON/ShiLtJ f -0.0432 0.1001 0.1535 -0.24
NON/ShiLtJ m -0.0171 0.1001 0.1796 -0.2139
NZW/LacJ f 0.0061 0.1001 0.2029 -0.1906
NZW/LacJ m 0.092 0.1001 0.2888 -0.1048
PL/J f -0.2605 0.1001 -0.0637 -0.4573
PL/J m -0.0395 0.1001 0.1573 -0.2363
RIIIS/J f 0.2729 0.1001 0.4696 0.0761
RIIIS/J m 0.0338 0.1001 0.2305 -0.163
SJL/J f -0.0231 0.1001 0.1736 -0.2199
SJL/J m 0.0724 0.1001 0.2691 -0.1244
SM/J f 0.2007 0.1001 0.3975 0.004
SM/J m 0.1638 0.1001 0.3605 -0.033
SWR/J f -0.0238 0.1001 0.173 -0.2205
SWR/J m 0.2743 0.0944 0.4598 0.0888


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.625 0.0708 0.7641 0.4859
A/J both -0.2102 0.0708 -0.0711 -0.3494
AKR/J both 0.4003 0.0708 0.5394 0.2611
BALB/cByJ both 0.1951 0.0708 0.3342 0.056
BALB/cJ both 0.0867 0.0633 0.2111 -0.0378
BTBR T+ Itpr3tf/J both -0.0734 0.0708 0.0657 -0.2125
BUB/BnJ both 0.2423 0.0733 0.3863 0.0983
C3H/HeJ both 0.1281 0.0708 0.2672 -0.0111
C57BL/10J both 0.3586 0.0733 0.5026 0.2146
C57BL/6J both 0.5717 0.0664 0.7022 0.4413
C57BLKS/J both 0.5247 0.0658 0.654 0.3954
C57BR/cdJ both 0.4335 0.0764 0.5837 0.2832
C57L/J both 0.4677 0.0708 0.6068 0.3286
CBA/J both 0.5513 0.0708 0.6904 0.4122
CE/J both 0.1318 0.0688 0.267 -0.0034
DBA/1J both 0.1266 0.0671 0.2586 -0.0054
DBA/2J both 0.2137 0.0671 0.3457 0.0817
FVB/NJ both 0.2714 0.0733 0.4154 0.1274
I/LnJ both 0.1934 0.0829 0.3564 0.0305
KK/HlJ both 0.4437 0.0764 0.5939 0.2934
LP/J both 0.0701 0.0708 0.2092 -0.0691
NOD/ShiLtJ both 0.5741 0.0708 0.7132 0.435
NON/ShiLtJ both -0.0302 0.0708 0.1089 -0.1693
NZW/LacJ both 0.0491 0.0708 0.1882 -0.0901
PL/J both -0.15 0.0708 -0.0109 -0.2891
RIIIS/J both 0.1533 0.0708 0.2924 0.0142
SJL/J both 0.0246 0.0708 0.1637 -0.1145
SM/J both 0.1823 0.0708 0.3214 0.0431
SWR/J both 0.1253 0.0688 0.2605 -0.0099




  GWAS USING LINEAR MIXED MODELS