ITP survival analysis:   17-a-estradiol

Intervention:   17-a-estradiol     non-feminizing steroid, anti-aging
Trial code: 17aE2_16m Dose: 14.4 ppm initiated at age: 16 mo Sex: m Cohort: C2016
Trial code: 17aE2_20m Dose: 14.4 ppm initiated at age: 20 mo Sex: m Cohort: C2016
This compound had a significant effect on survival:   16 mo males p < 0.0001; 20 mo males p = 0.0064

Results are based on the use of pooled factor(s) that is/are stratified within the survival analysis model.

All test sites combined – male
17aE2_16m effect on survival, males, test site = All
Log-rank test chisq = 21.6277 p < 0.0001
Wang-Allison test odds ratio = 2.5402 p = 0.0042
Quantiles 17aE2_16m Control % difference
25% died before day: 766 608 +26 %
Median lifespan (days) 920 782 +18 %
75% died before day: 1024 935 +10 %
90% died before day: 1110 1055 +5 %
Max lifespan observed (days) 1376 1264
Number of mice at start 151 275
Animal censor events are denoted by + marks in the plot
17aE2_20m effect on survival, males, test site = All
Log-rank test chisq = 7.4422 p = 0.0064
Wang-Allison test odds ratio = 1.6006 p = 0.1743
Quantiles 17aE2_20m Control % difference
25% died before day: 672 608 +11 %
Median lifespan (days) 873 782 +12 %
75% died before day: 997 935 +7 %
90% died before day: 1109 1055 +5 %
Max lifespan observed (days) 1361 1264
Number of mice at start 143 275
Animal censor events are denoted by + marks in the plot


By individual test site:

TJL – male
TJL – male      
17aE2_16m effect on survival, males, test site = TJL
Log-rank test chisq = 4.0613 p = 0.0439
Wang-Allison test odds ratio = 2.1496 p = 0.1672
Quantiles 17aE2_16m Control % difference
25% died before day: 706 608 +16 %
Median lifespan (days) 902 749 +20 %
75% died before day: 990 891 +11 %
90% died before day: 1059 1005 +5 %
Max lifespan observed (days) 1174 1262
Number of mice at start 54 94
Animal censor events are denoted by + marks in the plot
17aE2_20m effect on survival, males, test site = TJL
Log-rank test chisq = 6.0012 p = 0.0143
Wang-Allison test odds ratio = 3.1158 p = 0.0455
Quantiles 17aE2_20m Control % difference
25% died before day: 632 608 +4 %
Median lifespan (days) 873 749 +17 %
75% died before day: 1017 891 +14 %
90% died before day: 1116 1005 +11 %
Max lifespan observed (days) 1361 1262
Number of mice at start 51 94
Animal censor events are denoted by + marks in the plot
UM – male
UM – male      
17aE2_16m effect on survival, males, test site = UM
Log-rank test chisq = 3.6483 p = 0.0561
Wang-Allison test odds ratio = 2.258 p = 0.2218
Quantiles 17aE2_16m Control % difference
25% died before day: 752 534 +41 %
Median lifespan (days) 943 814 +16 %
75% died before day: 1028 996 +3 %
90% died before day: 1114 1071 +4 %
Max lifespan observed (days) 1213 1258
Number of mice at start 46 82
Animal censor events are denoted by + marks in the plot
17aE2_20m effect on survival, males, test site = UM
Log-rank test chisq = 2.075 p = 0.1497
Wang-Allison test odds ratio = 1.1549 p = 0.7704
Quantiles 17aE2_20m Control % difference
25% died before day: 758 534 +42 %
Median lifespan (days) 900 814 +11 %
75% died before day: 1020 996 +2 %
90% died before day: 1154 1071 +8 %
Max lifespan observed (days) 1250 1258
Number of mice at start 45 82
Animal censor events are denoted by + marks in the plot
UT – male
UT – male      
17aE2_16m effect on survival, males, test site = UT
Log-rank test chisq = 16.6022 p < 0.0001
Wang-Allison test odds ratio = 3.2921 p = 0.0412
Quantiles 17aE2_16m Control % difference
25% died before day: 850 640 +33 %
Median lifespan (days) 955 799 +20 %
75% died before day: 1067 936 +14 %
90% died before day: 1187 1064 +12 %
Max lifespan observed (days) 1376 1264
Number of mice at start 51 99
Animal censor events are denoted by + marks in the plot
17aE2_20m effect on survival, males, test site = UT
Log-rank test chisq = 0.6662 p = 0.4144
Wang-Allison test odds ratio = 1.0591 p = 1.0
Quantiles 17aE2_20m Control % difference
25% died before day: 665 640 +4 %
Median lifespan (days) 840 799 +5 %
75% died before day: 971 936 +4 %
90% died before day: 1038 1064 -2 %
Max lifespan observed (days) 1214 1264
Number of mice at start 47 99
Animal censor events are denoted by + marks in the plot


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Statistical definitions