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Project data set: Rusyn2   (2010)

Project Effects of trichloroethylene in males of 17 inbred mouse strains

An investigation into the effects of trichloroethylene. There were 3 cohorts: 1) naive mice; 2) control group orally administered vehicle (corn oil); 3) treated group orally administered trichloroethylene (TCE 2100 mg/kg) in vehicle.

Study design: control vs. an intervention; 3 cohorts.
17 strains tested     male only     Test age: 7wks
Sample sizes are 2.8 on average. ... Caution, some N ≤ 2 are present  [details]

Investigators Rusyn I, Threadgill DW     [Project details, papers, citing]

Part of a series: • Phenotype data ... this project ...   Rusyn2  
• Gene expression, control group ... see Rusyn3
• Gene expression, TCE group ... see Rusyn4

Protocol View phenotyping protocol and methods

Rusyn2
measurements



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blood — clinical chemistry         metabolic panel  
Rusyn2
alanine aminotransferase (serum ALT), naive   [IU/L] 17 strains   age 7wks
  Inbred
Rusyn2
alanine aminotransferase (serum ALT) [IU/L]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
ALT, control vs. treated   trichloroethylene      
2h  8h  24h 
age 7wks
  Inbred
Rusyn2
aspartate aminotransferase (serum AST), naive   [IU/L] 17 strains   age 7wks
  Inbred
Rusyn2
aspartate aminotransferase (serum AST) [IU/L]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
AST, control vs. treated   trichloroethylene      
2h  8h  24h 
age 7wks
  Inbred
Rusyn2
blood urea nitrogen (serum BUN), naive   [mg/dL] 17 strains   age 7wks
  Inbred
Rusyn2
blood urea nitrogen (serum BUN) [mg/dL]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
blood urea nitrogen (BUN), control vs. treated   trichloroethylene      
2h  8h  24h 
age 7wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         HPLC  
Rusyn2
dichloroacetic acid (serum DCA x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
trichloroacetic acid (serum TCA) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
DCV cysteine (serum DCVC x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
DCV glutathione (serum DCVG x 10-3) [nmol/mL]   trichloroethylene      
treated group:  • 2h  • 8h  • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
above metabolites compared   trichloroethylene      
treated group:  2h  8h  24h 
age 7wks
  Inbred


local experiment parameter  
Rusyn2
body weight, naive   [g] 17 strains   age 7wks
  Inbred
Rusyn2
body weight [g]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
body weight, control vs. treated   trichloroethylene      
2h  8h  24h 
age 7wks
  Inbred
Rusyn2
liver weight as percent of body weight, naive   [ratio] 17 strains   age 7wks
  Inbred
Rusyn2
liver weight as a percentage of body weight [%]     control and  trichloroethylene      
  control group:    • 2h    • 8h    • 24h      time comparison        
  treated group:    • 2h    • 8h    • 24h      time comparison  
17 strains   age 7wks
  Inbred
Rusyn2
adjusted liver weight, control vs. treated   trichloroethylene      
2h  8h  24h 
age 7wks
  Inbred


  
Reference
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6.     PubMed 21135412     MGI     FullText


Mice

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Changelog

No updates or corrections have been posted since MPD release in Apr 2011  

Note

Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics [View list]

Rusyn2
downloads


Individual animal data
Table format (.csv)
All individual animal data, table format, one row per animal and one column per measurement.
Individual animal data
List format (.csv)
All numeric animal data values, one row per animal per measurement.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
Supplemental data are available

 See also MPD's general data download page for other options.





 




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