MPD: Project measures / variables set: Rusyn2 AST

Project measures / variables set: Rusyn2 AST_ctrl

ID, description, units	MPD:36122 AST_ctrl aspartate transaminase (serum AST), control group [IU/L] trichloroethylene study
Measures	• time: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 16 strains sex: m age: 7wks
Procedure	metabolic panel
Comparison	timecourse but different cohorts
Ontology mappings	VT:0000203 blood aspartate transaminase amount VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0000203 abnormal circulating aspartate transaminase level MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Rusyn2 - aspartate transaminase (serum AST), control group

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	174522.5674	87261.2837	1.9757	0.1449
time:strain	28	1388662.0095	49595.0718	1.1229	0.3333
Residuals	86	3798299.5	44166.2733
strain	14	1190112.0605	85008.0043	1.9247	0.0344

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36122	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] 2h after baseline AST_2_ctrl	inbred	15	m	7wks
Rusyn2	36123	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] 8h after baseline AST_8_ctrl	inbred	16	m	7wks
Rusyn2	36124	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] 24h after baseline AST_24_ctrl	inbred	15	m	7wks