Sensitivity to diazepam. Purpose: To test the sensitivity of inbred strains of mice to acute low-dose stimulation and high-dose depression effects of diazepam (DZ) on locomotor activity, hypothermia, and incoordination on a rotarod.

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains behavior — activity and motor function &ndash animal monitoring system   Crabbe2 horizontal distance traveled (immediately to 15min post-injection) [cm]     baseline and  diazepam       • baseline  • 2 mg/kg  • 4 mg/kg  • 8 mg/kg  • 16 mg/kg    dose effect comparison   15 strains   age 6-7wks Crabbe2 vertical (rearing) activity (immediately to 15min post-injection) [n]     baseline and  diazepam       • baseline  • 2 mg/kg  • 4 mg/kg  • 8 mg/kg  • 16 mg/kg    dose effect comparison   15 strains   age 6-7wks   behavior — activity and motor function &ndash rotarod   Crabbe2 latency to fall from 5rpm rotarod, 0 min post-injection [s]   diazepam   20 mg/kg       • trial block1  • trial block2    trial block comparison   15 strains   age 6-7wks   brain — physiology and function — drug concentration   Crabbe2 brain diazepam and metabolite concentration (30min post-injection) [ng/g]   diazepam       • 8 mg/kg  • 16 mg/kg    dose effect comparison   15 strains   age 6-7wks Crabbe2 brain diazepam and metabolite concentration (<5min post-injection) after rotarod [ng/g]   diazepam   20 mg/kg       • trial block1  • trial block2    trial block comparison   15 strains   age 6-7wks   metabolism — body temperature   Crabbe2 body temperature (30min post-injection) [°C]     baseline and  diazepam       • baseline  • 2 mg/kg  • 4 mg/kg  • 8 mg/kg  • 16 mg/kg    dose effect comparison   15 strains   age 6-7wks Display strain means in the above table for: select a strain 129P3/J A/HeJ AKR/J BALB/cJ C3H/HeJ C57BL/6J C57BR/cdJ C57L/J CBA/J CE/J DBA/1J DBA/2J PL/J SJL/J SWR/J   Compare two strains: select strain 1 129P3/J A/HeJ AKR/J BALB/cJ C3H/HeJ C57BL/6J C57BR/cdJ C57L/J CBA/J CE/J DBA/1J DBA/2J PL/J SJL/J SWR/J vs. select strain 2 129P3/J A/HeJ AKR/J BALB/cJ C3H/HeJ C57BL/6J C57BR/cdJ C57L/J CBA/J CE/J DBA/1J DBA/2J PL/J SJL/J SWR/J   Compare female vs. male for: select a strain 129P3/J A/HeJ AKR/J BALB/cJ C3H/HeJ C57BL/6J C57BR/cdJ C57L/J CBA/J CE/J DBA/1J DBA/2J PL/J SJL/J SWR/J   Display overall measurement averages (all strains combined) in the above table

Notes

Crabbe JC, Gallaher EJ, Cross SJ, Belknap JK. Genetic determinants of sensitivity to diazepam in inbred mice. Behav Neurosci. 1998 Jun;112(3):668-77.     PubMed    MGI There have been no updates or corrections to the dataset since it was first released in Feb, 2009 All strain means have N ≥ 5 animals (click for table).

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Individual animal data Not accessioned Crabbe2 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Crabbe2 protocol document HTML Crabbe2 animal documentation HTML Supplemental data None