Lung inflammatory response to environmental stress: Ovalbumin. In response to community input, this project has been restructured to de-emphasize the Penh parameter, which is a controversial measure of airway responsiveness (see reference). Penh measurements (per-animal) are available as Supplementary data only. Additional data for allergen-induced inflammatory cells are now MPD measurements and eligible for analysis with MPD tools (eosinophils, lymphocytes, and neutrophils; data for these and all other cell types are available as Supplementary data).

Available measurements   Mice & strains       Protocol       Plots & tools wizard Change list style       Show varnames       Verbose listing       Display strain data     Compare 2 strains respiratory — inflammatory cells — allergen induced   Schwartz2 alveolar eosinophils [%]     control and  ovalbumin i.p.         pre-test:   • control    • OVA-sensitized    OVA effect comparison           24h post:   • control    • OVA-sensitized    OVA effect comparison           48h post:   • control    • OVA-sensitized    OVA effect comparison           72h post:   • control    • OVA-sensitized    OVA effect comparison           time curves:   control    OVA-sensitized  8 strains   age 6-8wks Schwartz2 alveolar lymphocytes [%]     control and  ovalbumin i.p.         pre-test:   • control    • OVA-sensitized    OVA effect comparison           24h post:   • control    • OVA-sensitized    OVA effect comparison           48h post:   • control    • OVA-sensitized    OVA effect comparison           72h post:   • control    • OVA-sensitized    OVA effect comparison           time curves:   control    OVA-sensitized  8 strains   age 6-8wks Schwartz2 alveolar neutrophils [%]     control and  ovalbumin i.p.         pre-test:   • control    • OVA-sensitized    OVA effect comparison           24h post:   • control    • OVA-sensitized    OVA effect comparison           48h post:   • control    • OVA-sensitized    OVA effect comparison           72h post:   • control    • OVA-sensitized    OVA effect comparison           time curves:   control    OVA-sensitized  8 strains   age 6-8wks Display strain means in the above table for: select a strain 129S1/SvImJ A/J BALB/cJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ   Compare two strains: select strain 1 129S1/SvImJ A/J BALB/cJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ vs. select strain 2 129S1/SvImJ A/J BALB/cJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ   Compare female vs. male for: select a strain 129S1/SvImJ A/J BALB/cJ BTBR T+ tf/J C3H/HeJ C57BL/6J DBA/2J FVB/NJ   Display overall measurement averages (all strains combined) in the above table

Notes

Whitehead GS, Walker JK, Berman KG, Foster WM, Schwartz DA. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L32-42. Epub 2003 Mar 07.     PubMed    MGI There have been 2 updates or corrections to the dataset since it was first released in Nov, 2004 Graphic showing cell differentials at all timepoints. Some strain means have N < 5 animals (click for table). Some measurements are ineligible for MPD-wide correlations (click for list). See also the investigators' web site. This is one of several projects supplied by Heart, Lung, Blood and Sleep Disorders Center.

Downloads             Help

The Schwartz2 project data set. Individual animal data in table format, with one row per animal and measurements organized as columns. Excel file Schwartz2 individual animal data in list format. Most or all of the same information* as the file above, but organized as one row per animal / measurement. Excel file Schwartz2 strain means, SD, SEM, N, Z-scores and other summary statistics. One row per strain / sex / measurement. Excel file These Excel files include data, descriptions, and units for all measurements listed above. Other download options are available via the Plots & Tools Wizard, above. Schwartz2 protocol document HTML Schwartz2 animal documentation HTML Supplemental data are available Click here for more info