Zhang1: Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice (2012)

Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-20Epub 2012 Jan 31.   PubMed 22294616     FullText


     
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Participants Z Zhang
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Rowlan JS, Wang Q, Shi W
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsGrant: The research was supported by grants from the National Institutes of Health (AR43618, RR08911-5,CA34196), the US Army (DAMA17-94-J-4016), and the S.D. Bechtel Foundation.
Project type QTL Archive data set
MPD identifiersZhang1     MPD:279
Data changelog No updates/corrections.       Initial release date: 07/2012.
Female F2 mice (n 266) were generated from an intercross between B6.Apoe -/- and BALB.Apoe -/- mice and fed a Western diet for 12 weeks. Atherosclerotic lesions in the aortic root, fasting plasma glucose, and body weight were measured. 130 microsatellite markers across the entire genome were genotyped. Four significant QTLs, Ath1 on chromosome (Chr) 1, Ath41 on Chr2, Ath42 on Chr5, and Ath29 on Chr9, and 1 suggestive QTL on Chr4, were identified for atherosclerotic lesion size. Four significant QTLs, Bglu3 and Bglu12 on Chr1, Bglu13 on Chr5, Bglu15 on Chr12, and 2 suggestive QTLs on Chr9 and Chr15 were identified for fasting glucose levels on the chow diet. Two significant QTLs, Bglu3 and Bglu13, and 1 suggestive locus on Chr8 were identified for fasting glucose on the Western diet. One significant locus on Chr1 and 2 suggestive loci on Chr9 and Chr19 were identified for body weight. Ath1 and Ath42 coincided with Bglu3 and Bglu13, respectively, in the confidence interval.


QTL data set parameters:
Progenitor strains BALB/cJ Apoe-/-     C57BL/6J Apoe-/-    
Cross direction notationboth
Cross typeF2 intercross
Population size 266 ♀     0 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Zhang1 27901 body weight western diet  12wks weight   [g]  Weight QTL population f 18wks N=266
Zhang1 27902 colony observation western diet  12wks skin color  Skin_color QTL population f 18wks N=266
Zhang1 27903 histopathology western diet  12wks maximal carotid lesion   [µm2]  Carotid_lesion_max QTL population f 18wks N=266
Zhang1 27904 histopathology western diet  12wks maximal lesion, ln transformed  Carotid_lesion_LnMax QTL population f 18wks N=266
Zhang1 27905 histopathology western diet  12wks maximal lesion, log transformed  Carotid_lesion_L10Max QTL population f 18wks N=266
Zhang1 27906 histopathology western diet  12wks maximal lesion, square root  Carotid_lesion_MasSQ QTL population f 18wks N=266
Zhang1 27907 histopathology western diet  12wks average maximal 5 lesion   [µm2/section]  Carotid_lesion_Amax5 QTL population f 18wks N=266
Zhang1 27908 histopathology western diet  12wks average maximal 5 lesion, ln transformed  Carotid_lesion_LnAmax5 QTL population f 18wks N=266
Zhang1 27909 histopathology western diet  12wks average maximal 5 lesion, log transformed  Carotid_lesion_L10Am5 QTL population f 18wks N=266
Zhang1 27910 histopathology western diet  12wks average maximal 5 lesion, square root  Carotid_lesion_Am5sq QTL population f 18wks N=266
Zhang1 27911 histopathology western diet  12wks average lesion   [µm2/section]  Carotid_lesion_average QTL population f 18wks N=266
Zhang1 27912 histopathology western diet  12wks average lesion, ln transformed  Carotid_lesion_LnAvg QTL population f 18wks N=266
Zhang1 27913 histopathology western diet  12wks average lesion, log transformed  Carotid_lesion_L10Avg QTL population f 18wks N=266
Zhang1 27914 histopathology western diet  12wks average lesion, square root  Carotid_lesion_AvgSq QTL population f 18wks N=266
Zhang1 27915 histopathology western diet  12wks lesion double-checked   [µm2/section]  Carotid_lesion-recheck QTL population f 18wks N=266
Zhang1 27916 histopathology western diet  12wks maximal lesion   [µm2]  Aortic_lesion_Max QTL population f 18wks N=266
Zhang1 27917 histopathology western diet  12wks average lesion   [µm2/section]  Aortic_lesion_Aveg QTL population f 18wks N=266
Zhang1 27918 histopathology western diet  12wks average maximal 5 lesion   [µm2/section]  Aortic_lesion_Amax5 QTL population f 18wks N=266
Zhang1 27919 histopathology western diet  12wks average maximal 5 lesion, ln transformed  Aortic_lesion_LnAmax5 QTL population f 18wks N=266
Zhang1 27920 histopathology western diet  12wks maximal lesion, square root  Aortic_lesion_Max_Sqrt QTL population f 18wks N=266
Zhang1 27921 histopathology western diet  12wks average lesion, square root  Aortic_lesion_Avg_sqrt QTL population f 18wks N=266
Zhang1 27922 histopathology western diet  12wks average maximal 5 lesion, square root  Aortic_lesion_Amax5_sqrt QTL population f 18wks N=266
Zhang1 27923 histopathology western diet  12wks maximal lesion, ln transformed  Aortic_lesion_Max_LN QTL population f 18wks N=266
Zhang1 27924 histopathology western diet  12wks average lesion, ln transformed  Aortic_lesion_Avg_LN QTL population f 18wks N=266
Zhang1 27926 histopathology western diet  12wks maximal 10 lesion   [µm2/section]  Aortic_lesion_Max10 QTL population f 18wks N=266
Zhang1 27927 histopathology western diet  12wks average lesion, log10 transformed  Aortic_lesion_Aveg_log10 QTL population f 18wks N=266
Zhang1 27928 lipid profile (none) plasma total cholesterol, chow   [mg/dL]  Total_Cholesterol QTL population f <6wks N=266
Zhang1 27929 lipid profile (none) plasma free cholesterol, chow   [mg/dL]  Free_Cholesterol QTL population f <6wks N=266
Zhang1 27930 lipid profile (none) plasma cholesterol ester, chow   [mg/dL]  Cholesterol_ester,_Chow QTL population f <6wks N=266
Zhang1 27931 lipid profile (none) HDL cholesterol, chow   [mg/dL]  HDL_Chow QTL population f <6wks N=266
Zhang1 27932 lipid profile (none) LDL cholesterol, chow   [mg/dL]  LDL_Chow QTL population f <6wks N=266
Zhang1 27933 lipid profile (none) plasma triglyceride, chow   [mg/dL]  Triglyceride_Chow QTL population f <6wks N=266
Zhang1 27934 lipid profile (none) ln( triglyceride ), chow  Ln_Triglyceride_Chow QTL population f <6wks N=266
Zhang1 27935 lipid profile western diet  12wks plasma total cholesterol   [mg/dL]  Total_Cholesterol_Western QTL population f 18wks N=266
Zhang1 27936 lipid profile western diet  12wks plasma free cholesterol   [mg/dL]  Free_Cholesterol_Western QTL population f 18wks N=266
Zhang1 27937 lipid profile western diet  12wks plasma cholesterol ester   [mg/dL]  Cholesterol_ester,_Western QTL population f 18wks N=266
Zhang1 27938 lipid profile western diet  12wks HDL cholesterol   [mg/dL]  HDL_Western QTL population f 18wks N=266
Zhang1 27939 lipid profile western diet  12wks LDL cholesterol, chow   [mg/dL]  LDL_Western QTL population f 18wks N=266
Zhang1 27940 lipid profile western diet  12wks ln( HDL )  Ln_HDL_Western QTL population f 18wks N=266
Zhang1 27941 lipid profile western diet  12wks plasma triglyceride   [mg/dL]  Triglyceride_Western QTL population f 18wks N=266
Zhang1 27942 metabolic panel western diet  12wks plasma glucose   [mg/dL]  Glucose_Western QTL population f 18wks N=266
Zhang1 27943 metabolic panel (none) plasma glucose, chow   [mg/dL]  Glucose_Chow QTL population f <6wks N=266
Zhang1 27944 hormone quantification western diet  12wks plasma insulin   [ng/mL]  Insulin_mean QTL population f 18wks N=266
Zhang1 27945 hormone quantification western diet  12wks ln( insulin )  Ln_insulin QTL population f 18wks N=266
Zhang1 27946 histopathology western diet  12wks total aortic lesion size   [µm2]  Aortic_lesion_Sum QTL population f 18wks N=266
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Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Ath41   Ath42   Bglu12   Bglu13   Bglu14   Bglu15  


Project / data set:   Zhang1     a.k.a. Zhang_2012
Excel file:   Data_Description_BL6xBALB_Zhang2012.xlsx
CSV file:   Zhang2012_BL6xBALB_B37_Data.csv
Readme / text file:   readme_Zhang2012.txt
QC plots, figures, etc.:   QCReport_Zhang2012.pdf