Yuan5: QTL analysis of circulating adhesion molecules in apoE-/- mice (2008)

Yuan Z, Su Z, Miyoshi T, Rowlan JS, Shi W. Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice. Mol Genet Genomics. 2008 Nov;280(5):375-83. Epub 2008 Aug 13.   PubMed 18704499     FullText

Yuan5 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants Z Yuan
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Su Z, Miyoshi T, Rowlan JS, Shi W
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsGrant: The current study was supported by the National Institutes of Health grant HL75433 and by the NHLBI Mammalian Genotyping Service (contract HV48141) for the genotyping.
Project type QTL Archive data set
MPD identifiersYuan5     MPD:211
Data changelog No updates/corrections.       Initial release date: 03/2011.
Circulating soluble adhesion molecules are useful markers to predict several clinical conditions. To determine genetic factors influencing plasma levels of VCAM-1 and P-selectin, authors performed QTL analysis on an intercross between B6 and C3H strains deficient in apolipoprotein E. 234 female F2 mice were selected to do the experiments, and the analysis results indicate VCAM-1 and P-selectin levels are complex traits regulated by multiple genes, at least partially, by acting on body weight and lipid metabolism in hyperlipidemic apoE-/- mice.

QTL data set parameters:
Progenitor strains B5.apoE-/-     C3H.apoE-/-    
Cross direction notation(B6xC3H) F1 x (B6xC3H) F1
Cross typeF2 intercross
Population size 234 ♀     0 ♂

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Yuan5 21101 biomarker quantification (none) plasma levels of P-selectin   [ng/mL]  P-selectin QTL population f 18wks N=234
Yuan5 21102 biomarker quantification (none) plasma levels of soluble vascular cell adhesion molecule-1   [ng/mL]  VCAM1 QTL population f 18wks N=234

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Ppsl   Pvacm1l  

Project / data set:   Yuan5     a.k.a. Yuan_2008
Excel file:   Data_Description_B6xC3H_Yuan2008.xlsx
CSV file:   Yuan2008_B6xC3H_B37_Data.csv
Readme / text file:   readme_Yuan2008.txt