Yi1: QTL analysis of organ and body weights in M16i x CAST backcross (2007)

References   (chronological)

1.   Leamy LJ, Pomp D, Eisen EJ, Cheverud JM. Quantitative trait loci for directional but not fluctuating asymmetry of mandible characters in mice. Genet Res. 2000 Aug;76(1):27-40.   PubMed 11006632  

2.   Leamy LJ, Pomp D, Eisen EJ, Cheverud JM. Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice. Physiol Genomics. 2002 Jul 12;10(1):21-9.   PubMed 12118102  

3.   Yi N, Yandell BS, Churchill GA, Allison DB, Eisen EJ, Pomp D. Bayesian model selection for genome-wide epistatic quantitative trait loci analysis. Genetics. 2005 Jul;170(3):1333-44. Epub 2005 May 23.   PubMed 15911579     FullText

Yi1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants N Yi
James M Cheverud       Washington University School of Medicine St. Louis, MO
With: Leamy LJ, Pomp D, Eisen EJ
ContactJames M Cheverud     cheverud@pcg.wustl.edu
AffiliationChurchill Group QTL Archive
AcknowledgementsPlease see the Excel file for complete listing of grants.
Project type QTL Archive data set
MPD identifiersYi1     MPD:206
Data changelog No updates/corrections.       Initial release date: 04/2010.
To investigate genes which control the components of body weight, a backcross of M16i and CAST/Ei was generated to identify the quantitative trait loci (QTLs) affecting body weight and organ weights. Mice were fed with Purina Laboratory Chow 5001 from weaning to death and weighed at different times. The organs were weighed when mice reached 12 weeks of age. For detailed protocols see Leamy et al 2002.

QTL data set parameters:
Progenitor strains CAST/EiJ     M16i    
Cross direction notationM16i x (M16i x CAST)
Cross typeBackcross
Population size 207 ♀     212 ♂

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Yi1 20601 body weight (none) body weight at day 12   [g]  bw12d QTL population both 2wks N=210
Yi1 20602 body weight (none) body weight at week 3   [g]  bw3wk QTL population both 3wks N=210
Yi1 20603 body weight (none) body weight at week 6   [g]  bw6wk QTL population both 6wks N=210
Yi1 20604 body weight (none) body weight at week 9   [g]  bw9wk QTL population both 9wks N=210
Yi1 20605 body weight (none) body weight at week 12   [g]  bw12wk QTL population both 12wks N=210
Yi1 20606 organ weights (none) liver weight at week 12   [mg]  liver12wk QTL population both 12wks N=210

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Daq17   Daq18   Daq19   Lmblgq1   Lmblgq2   Lmblgq3   Lmblgq4   Lmblgq5   Lmblgq6   Orgwq1   Orgwq2   Orgwq3   Orgwq4   Orgwq5   Orgwq6   Orgwq7   Orgwq8   Orgwq9  

Project / data set:   Yi1     a.k.a. Yi_2007
Excel file:   Data_Description_M16ixCast_Yi2007.xlsx
CSV file:   Yi2007_M16ixCast_B37_Data.csv
Readme / text file:   readme_Yi2007.txt