Wergedal1: Bone Mineral Density (BMD) and related bone phenotypes in a NZB/BlNJ and RF/J F2 intercross (2006)

Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ. Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. J Bone Miner Res. 2006 Aug;21(8):1256-66.   PubMed 16869724  

Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug;25(8):1808-20.   PubMed 20200990  


     
Wergedal1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants J E Wergedal
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Baylink DJ
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis material is based on work supported in part by the Office of Research and Development (R&D), Medical Research Service, Department of Veteran Affairs. This work was supported by the following grants from the NIH: AR-46204 (JEW), AR-43618 (WGB), and GM070683 (GAC).
Project type QTL Archive data set
MPD identifiersWergedal1     MPD:189
Data changelog No updates/corrections.       Initial release date: 10/2009.
This cross is designed to identify the genetic loci regulating femur mechanical properties, geometric properties, and BMD in a cohort of F2 mice derived from intercross matings of (NZB/B1NJ x RF/J)F1 parents. Total of 661 female F2 mice with 94 genetic markers on autosomes were analyzed with pseudomarker version 1.02 in 2003-2004. For detailed protocols see Wergedal et al 2006.


QTL data set parameters:
Progenitor strains NZB/BlNJ     RF/J    
Cross direction notation(NZB x RF) F1 x (NZB x RF) F1
Cross typeF2 intercross
Population size 661 ♀     0 ♂
Age10wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Wergedal1 18901 DXA (none) total femur volumetric bone mineral density (BMD)   [mg/cm3]  Ftotden QTL population f 10wks N=661
Wergedal1 18902 biomechanical test (none) maximum (ultimate) load   [N]  P QTL population f 10wks N=661
Wergedal1 18903 DXA (none) cortical thickness   [mm]  CrtThk QTL population f 10wks N=661

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Fmtq1   Fmtq10   Fmtq11   Fmtq12   Fmtq13   Fmtq14   Fmtq15   Fmtq16   Fmtq17   Fmtq18   Fmtq19   Fmtq2   Fmtq20   Fmtq21   Fmtq3   Fmtq4   Fmtq5   Fmtq6   Fmtq7   Fmtq8   Fmtq9  


Project / data set:   Wergedal1     a.k.a. Wergedal_2006
Excel file:   Data_Description_NZBxRF_Wergedal2006.xlsx
CSV file:   Wergedal2006_NZBxRF_B37_Data.csv
Readme / text file:   readme_Wergedal2006.txt