Sundberg2: Alopecia Areata in F2 progeny in a C3H/HeJ x C57BL/6J intercross (2003)

Sundberg JP, Boggess D, Silva KA, McElwee KJ, King LE, Li R, Churchill G, Cox GA. Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol. 2003 May;120(5):771-5.   PubMed 12713579  


     
Sundberg2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants John P Sundberg       The Jackson Laboratory Bar Harbor, ME
With: Boggess D, Silva KA, McElwee KJ, King LE, Li R, Churchill G, Cox GA
ContactJohn P Sundberg     john.sundberg@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH AR43801, RR173, AR41443, CA34196; and from the National Alopecia Areata Foundation, Council for Nail Research, Dermatology Foundation/Glaxo, and Department of Veterans Affairs
Project type QTL Archive data set
MPD identifiersSundberg2     MPD:135
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross of C3H/HeJ and C57BL/6J was generated to identify QTLs for susceptibility to the autoimmune disease, Alopecia areata. F2 progeny were examined at 1 year of age and scored using both gross and histological criteria. For detailed protocols see Sundberg et al 2003.


QTL data set parameters:
Progenitor strains C3H/HeJ     C57BL/6J    
Cross typeF2 intercross
Population size 354 ♀     13 ♂
Age1yr


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Sundberg2 13501 histopathology (none) Alopecia areata diagnosis (score 0=no alopecia, 1=alopecia)   [score]  alopecia_score QTL population both 1yr N=184

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Alaa1  


Project / data set:   Sundberg2     a.k.a. Sundberg_2003
Excel file:   Data_Description_B6xC3H_Sundberg2003.xlsx
CSV file:   Sundberg2003_B6xC3H_B37_Data.csv
Readme / text file:   readme_Sundberg2003.txt