Sugiyama2: Blood pressure in males of reciprocal backcrosses between C57BL/6J (salt-sensitive) and A/J (non-salt-sensitive) (2001)

Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7.   PubMed 11161799  

Sen S, Churchill GA. A statistical framework for quantitative trait mapping. Genetics. 2001 Sep;159(1):371-87.   PubMed 11560912  


     
Sugiyama2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants Fimihiro Sugiyama       University of Tsukuba Tsukuba JAPAN
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Sen S
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH HL55001, CA34196; Japanese Ministry of Education, Science, Sport, and Culture
Project type QTL Archive data set
MPD identifiersSugiyama2     MPD:119
Data changelog No updates/corrections.       Initial release date: 01/2008.
To investigate the genetic control of salt-induced hypertension, a QTL analysis was performed on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains. At 8 wks of age, progeny were provided with drinking water containing 1% NaCl for 2 wks. Blood pressure was measured using the tail cuff method. See Sugiyama et al, 2001 (below) for procedural details and sampling methods.


QTL data set parameters:
Progenitor strains A/J     C57BL/6J    
Cross typeReciprocal backcross
Population size 0 ♀     250 ♂
Age10wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Sugiyama2 11901 tail cuff sodium chloride  1%soln 2wks systolic blood pressure   [mmHg]  BP_salt QTL population m 10wks N=250

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Bpq1   Bpq2   Bpq3   Bpq4   Bpq5   Bpq6  


Project / data set:   Sugiyama2     a.k.a. Sugiyama_2001
Excel file:   Data_Description_B6xA_BC_Sugiyama2001.xlsx
CSV file:   Sugiyama2001_B6xA_BC_B37_Data.csv
Readme / text file:   readme_Sugiyama2001.txt