Stylianou1: Weight and distribution of fat pads in F2 progeny of SM/J x NZB/BlNJ (2006)

Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA. Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36. Epub 2006 Jan 13.   PubMed 16416088  


     
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Participants Ioannis M Stylianou       Xenon Pharmaceuticals Burnaby, British Columbia CANADA
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Korstanje R, Li R, Sheehan S, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH HL66611, GM070683, CA34196.
Project type QTL Archive data set
MPD identifiersStylianou1     MPD:184
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross of 513 F(2) progeny between the SM/J x NZB/BlNJ inbred mouse strains was generated to identify QTLs that are involved in the weight of four fat pads: mesenteric, inguinal, gonadal, and retroperitoneal. Mice were administered a high fat (15%) diet from 8 to 24 wks of age (16 wks on high fat diet). For a detailed protocol see Stylianou et al 2006.


QTL data set parameters:
Progenitor strains NZB/BlNJ     SM/J    
Cross typeF2 intercross
Population size 259 ♀     254 ♂
Age24wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Stylianou1 18401 body weight high fat diet  16wks body weight   [g]  bw QTL population both 24wks N=257
Stylianou1 18402 body weight high fat diet  16wks body weight, log transformed   [log(g)]  log_bw QTL population both 24wks N=257
Stylianou1 18403 body size and weight high fat diet  16wks body length   [cm]  length QTL population both 24wks N=257
Stylianou1 18404 body size and weight high fat diet  16wks body length, log transformed   [log(cm)]  log_length QTL population both 24wks N=257
Stylianou1 18405 fat pad weights high fat diet  16wks total weight of all fat pads   [g]  fat_pads QTL population both 24wks N=257
Stylianou1 18406 fat pad weights high fat diet  16wks total weight of all fat pads, log transformed   [log(g)]  log_fat_pads QTL population both 24wks N=257
Stylianou1 18407 fat pad weights high fat diet  16wks inguinal fat pad weight (left)   [g]  inguinal QTL population both 24wks N=257
Stylianou1 18408 fat pad weights high fat diet  16wks inguinal fat pad weight (total)   [g]  inguinal_tot QTL population both 24wks N=257
Stylianou1 18409 fat pad weights high fat diet  16wks inguinal fat pads, normalized to total fat pads, log transformed   [log(ratio)]  log_inguinal QTL population both 24wks N=257
Stylianou1 18410 fat pad weights high fat diet  16wks gonadal fat pad weight (left)   [g]  gonadal QTL population both 24wks N=257
Stylianou1 18411 fat pad weights high fat diet  16wks gonadal fat pad weight (total)   [g]  gonadal_tot QTL population both 24wks N=257
Stylianou1 18412 fat pad weights high fat diet  16wks gonadal fat pads, normalized to total fat pads, log transformed   [log(ratio)]  log_gonadal QTL population both 24wks N=257
Stylianou1 18413 fat pad weights high fat diet  16wks retroperitoneal fat pad weight (left)   [g]  peritoneal QTL population both 24wks N=257
Stylianou1 18414 fat pad weights high fat diet  16wks retroperitoneal fat pad weight (total)   [g]  peritoneal_tot QTL population both 24wks N=257
Stylianou1 18415 fat pad weights high fat diet  16wks retroperitoneal fat pads, normalized to total fat pads, log transformed   [log(ratio)]  log_peritoneal QTL population both 24wks N=257
Stylianou1 18416 fat pad weights high fat diet  16wks mesenteric fat pad weight   [g]  mesenteric QTL population both 24wks N=257
Stylianou1 18417 fat pad weights high fat diet  16wks mesenteric fat pad, normalized to total fat pads, log transformed   [log(ratio)]  log_mesenteric QTL population both 24wks N=257
Stylianou1 18418 fat pad weights high fat diet  16wks adiposity index (total fat pad weight normalized to lean body weight)   [%]  AI QTL population both 24wks N=257
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Project / data set:   Stylianou1     a.k.a. Stylianou_2006

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