Spijker1: Sensorimotor gating and attentional performance in males of 45 BXD recombinant inbred and other mouse strains (2011)

Loos M, Staal J, Pattij T; Neuro-BSIK Mouse Phenomics Consortium, Smit AB, Spijker S. Independent genetic loci for sensorimotor gating and attentional performance in BXD recombinant inbred strains. Genes Brain Behav. 2012 Mar;11(2):147-56. doi: 10.1111/j.1601-183X.2011.00754.x. Epub 2011 Dec 13.   PubMed 22098762  


       
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Participants Sabine Spijker       VU University Amsterdam Amsterdam NETHERLANDS
With: Loos M, Staal J, Pattij T, Smit AB, Neuro-BSIK Mouse Phenomics Consortium
ContactSabine Spijker     sabine.spijker@falw.vu.nl     Lab web site
Project type Phenotype strain survey data set
MPD identifiersSpijker1     MPD:406
Data changelog No updates/corrections.       Initial release date: 07/2012.
Formatted citation
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Summary of procedures that were conducted
• acoustic startle test Acoustic startle response, prepulse inhibition.
• choice serial reaction time task Choice serial reaction time task. Impulsivity, attention, cognitive flexibility behavior.
Mice: BXD   45 strains including progenitors   ♂   age 8wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Spijker1 40601 acoustic startle test (none) acoustic startle response (ASR)   [amplitude]     65dB    70dB    75dB    80dB    90dB    100dB    110dB    120dB BXD w/par 39 m 8wks N=11
    Spijker1 40613 acoustic startle test (none) prepulse inhibition (PPI)   [%]     120 dB startle intensity with prepulse stimulus:    65dB    70dB    75dB    80dB BXD w/par 36 m 8wks N=9
    Spijker1 40617 acoustic startle test (none) prepulse intensity 10 dB lower than startle threshold   [amplitude]  PPI_belowST BXD w/par 36 m 8wks N=9
    Spijker1 40618 acoustic startle test (none) startle threshold, minimum stimulus intensity where startle is significant compared to null period   [dB]  startle_threshold BXD w/par 39 m 8wks N=11
    Spijker1 40619 choice serial reaction time task (none) percent of total reponses that are correct, stimulus duration fixed, 1s   [%]  accuracy_SD1 BXD w/par 43 m 8wks N=13
    Spijker1 40620 choice serial reaction time task (none) percent of events that are omission errors, stimulus duration fixed, 1s   [%]  omission_SD1 BXD w/par 43 m 8wks N=13
    Spijker1 40621 choice serial reaction time task (none) correct response latency, stimulus duration fixed, 1s   [s]  latency_correct BXD w/par 43 m 8wks N=13
    Spijker1 40622 choice serial reaction time task (none) mode of correct reponse latencies, stimulus duration fixed, 1s   [s]  latency_mode BXD w/par 43 m 8wks N=13
    Spijker1 40623 choice serial reaction time task (none) individual variability of correct response latency   [s]  variability_SD1 BXD w/par 43 m 8wks N=13
    Spijker1 40624 choice serial reaction time task (none) latency between correct response and head entry detected in food magazine, stimulus duration fixed, 1s   [s]  latency_reward BXD w/par 43 m 8wks N=13
    Spijker1 40625 choice serial reaction time task (none) number of initiated trials (stimulus duration=1s)   [n]  trials_initiated BXD w/par 43 m 8wks N=13
    Spijker1 40626 choice serial reaction time task (none) percent of total reponses that are correct, stimulus duration variable   [%]  accuracy_SDvar BXD w/par 43 m 8wks N=13
    Spijker1 40627 choice serial reaction time task (none) percent of events that are omission errors, stimulus duration variable   [%]  omission_SDvar BXD w/par 43 m 8wks N=13
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