Sheehan1: Urinary albumin concentration in F2 male mice from C57BL/6J x DBA/2J intercross (2007)

Sheehan S, Tsaih SW, King BL, Stanton C, Churchill GA, Paigen B, DiPetrillo K. Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1649-56. Epub 2007 Sep 5.   PubMed 17804484  


     
Sheehan1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants Susan M Sheehan       The Jackson Laboratory Bar Harbor, ME
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Tsaih SW, King BL, Stanton C, Paigen B, DiPetrillo K
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grant DK-69381 (B. Paigen) and National Institute of General Medical Sciences Grant GM-070683 (G. A. Churchill).
Project type QTL Archive data set
MPD identifiersSheehan1     MPD:205
Data changelog No updates/corrections.       Initial release date: 10/2009.
This cross is designed to identify the genetic loci that control albuminuria in an intercross: C57BL/6J x DBA/2J (BxD). All of the F2 animals are males and all F1s came from B6 females crossed with DBA/2 males. The cross size is 340 male F2 animals. Only urinary albumin, urinary creatinine and the ratio of albumin to creatinine (ACR) are included in these 2 cross files (files 1 and 2). The QTL analyses were done in 2005 and 2006 using R/qtl. This cross was originally typed with 91 SNP markers and their cM positions were provided by the Paigen Lab directly. We identified problem markers and removed them prior to our analysis (see notes in the Readme file). For detailed protocols see Sheehan et al 2007.


QTL data set parameters:
Progenitor strains C57BL/6J     DBA/2J    
Cross direction notation(B6xDBA/2) F1 x (B6xDBA/2) F1
Cross typeF2 intercross
Population size 0 ♀     340 ♂
Age10wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Sheehan1 20501 urinalysis (none) urinary creatinine   [mg/dL]  UCreat QTL population m 10wks N=340
Sheehan1 20502 urinalysis (none) urinary albumin   [mg/dL]  Microalb QTL population m 10wks N=340
Sheehan1 20503 urinalysis (none) ratio of albumin to creatinine   [mg/g]  Alb/Creat QTL population m 10wks N=340

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Albq5   Albq6   Albq7   Albq8   Albq9  


Project / data set:   Sheehan1     a.k.a. Sheehan_2007
Excel file:   Data_Description_B6xDBA2_Sheehan2007.xlsx
CSV file:   Sheehan2007_B6xDBA2_B37_Data.csv
Readme / text file:   readme_Sheehan2007.txt