Sandell1: Ear wound healing and articular cartilage regeneration in 6 inbred and 9 LGXSM recombinant inbred strains of mice (2012)

Rai MF, Hashimoto S, Johnson EE, Janiszak KL, Fitzgerald J, Heber-Katz E, Cheverud JM, Sandell LJ. Heritability of articular cartilage regeneration and its association with ear wound healing in mice. Arthritis Rheum. 2012 Jul;64(7):2300-10. doi: 10.1002/art.34396.   PubMed 22275233     FullText

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Participants Linda J Sandell       Washington University School of Medicine St. Louis, MO
With: Rai MF, Hashimoto S, Johnson EE, Janiszak KL, Fitzgerald J, Heber-Katz E, Cheverud JM
ContactLinda J Sandell
AcknowledgementsFunding provided by NIH AR058978, AR057235, AR060719; Washington University Musculoskeletal Research Center at Barnes-Jewish Hospital
Project type Phenotype strain survey data set
MPD identifiersSandell1     MPD:498
Data changelog 1 update/correction.       Initial release date: 05/2014.
Formatted citation
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Bilateral ear punctures were made in 6-wk old mice and healing outcomes were measured after 30 d. At 8 wks of age, acute full-thickness articular cartilage injuries were introduced in the trochlear groove. Mouse knee joints were sectioned at indicated times post-injury and stained to evaluate regeneration. Time course analysis showed no significant regeneration until 16 wks post-wounding.

Summary of procedures that were conducted
• health assessment Post-injury wound healing. Ear cartilage and articular cartilage.
• histopathology Post-injury wound healing. Articular cartilage at 12wks and 16wks post-injury.
Mice: LGXSM   15 strains including progenitors   ♀♂   age 6-7wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Sandell1 49801 health assessment (none) ear cartilage wound healing 30d post-injury   [mm]  ear LGXSM w/par 13 both 10wks N=7
    Sandell1 49802 histopathology (none) articular cartilage wound healing at 12 wks post-injury   [score]  articular_12 LGXSM w/par 14 both 20wks N=6
    Sandell1 49803 histopathology (none) articular cartilage wound healing at 16 wks post-injury   [score]  articular_16 LGXSM w/par 10 both 24wks N=4
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