Rodriguez1: Identification of QTL that affects MCMV resistance in F2 progeny of NZW and NZB (2009)

Rodriguez MR, Lundgren A, Sabastian P, Li Q, Churchill G, Brown MG. A Cmv2 QTL on chromosome X affects MCMV resistance in New Zealand male mice. Mamm Genome. 2009 Jul;20(7):414-23. Epub 2009 Jul 30.   PubMed 19641964     FullText


     
Rodriguez1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants M R Rodriguez
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Lundgren A, Sabastian P, Li Q, Brown MG
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by NIH grants AI050072 (MGB), AR045222 (S.M. Fu and MGB), GM070683 (GC and QL). M. Rodriguez received support from an NIH Research Supplement to Promote Diversity (AI050072-06S1).
Project type QTL Archive data set
MPD identifiersRodriguez1     MPD:241
Data changelog No updates/corrections.       Initial release date: 08/2011.
NK cell-mediated resistance to viruses is subject to genetic control in humans and mice. To examine NK-mediated murine cytomegalovirus (MCMV) control in mice, an F2 intercross between NZW (MCMV resistance strain) and NZB (MCMV nonresistance strain) were generated to identify the loci affecting early MCMV control and enhancing viral resistance. 183 F2 mice were tested and the anlysis result showed a major X-linked locus affected antiviral responses. For detailed protocols, see Rodriguez et al 2009.


QTL data set parameters:
Progenitor strains NZB/BlNJ     NZW/LacJ    
Cross direction notation(NZWxNZB) F1 x (NZWxNZB) F1
Cross typeF2 intercross
Population size 99 ♀     84 ♂
Age8-12wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Rodriguez1 24101 in vitro assay (none) spleen and liver murine cytomegalovirus genome levels   [PFU]  CMV_LEVELS QTL population both 8-12wks N=92

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Cmv2  


Project / data set:   Rodriguez1     a.k.a. Rodriguez_2009
Excel file:   Data_Description_NZWxNZB_Rodriguez2009.xlsx
CSV file:   Rodriguez2009_NZWxNZB_B37_Data.csv
Readme / text file:   readme_Rodriguez2009.txt