Reifsnyder1: Age-related body weight and composition, plasma glucose, insulin, leptin and lipids in backcross mice (involving NZO/HlLtJ and NON/ShiLtJ) (2000)

Reifsnyder PC, Churchill G, Leiter EH. Maternal environment and genotype interact to establish diabesity in mice. Genome Res. 2000 Oct;10(10):1568-78.   PubMed 11042154  

Su Z, Ishimori N, Chen Y, Leiter EH, Churchill GA, Paigen B, Stylianou IM. Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. J Lipid Res. 2009 Oct;50(10):2083-94. Epub 2009 May 12.   PubMed 19436067  


     
Reifsnyder1 downloads
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Participants Peter C Reifsnyder       The Jackson Laboratory Bar Harbor, ME
With: Churchill G, Leiter EH
ContactPeter C Reifsnyder     peter.reifsnyder@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsResearch was supported by National Institutes of Health-National Center for Research Resources 88911. Institutional shared services were supported by National Cancer Institute Center Support Grant CA34196. Also funded by US National Institutes of Health grants to B.P. (HL-81162, HL-74086, and HL-77796) and GM-070683 to G.A.C., by American Heart Association Grant 0725905T to Z.S., and by the Novartis Institutes for Biomedical Research.
Project type QTL Archive data set
MPD identifiersReifsnyder1     MPD:111
Data changelog No updates/corrections.       Initial release date: 10/2009.
To identify diabetes-predisposing QTLs, NZO/HlLtJ mice (obese, diabetes-prone) were outcrossed with NONShiLtJ mice (non-obese, non-diabetic) to generate F1 hybrids. F1s of both sexes were backcrossed (reciprocal) with NON/ShiLtJ. Various parameters were tested from 4-24 wks of age. Body weight, plasma glucose, insulin, and, leptin were measured in four-week intervals, and fat pads were harvested at 24 wks of age. For detailed protocols, see Reifsnyder et al 2000.


QTL data set parameters:
Progenitor strains NON/ShiLtJ     NZO/HlLtJ    
Cross direction notation(NZOxNON) x NON; (NONxNZO) x NON;NON x (NZOxNON); NON x (NONxNZO)
Cross typeReciprocal backcross
Population size 0 ♀     204 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Reifsnyder1 11101 body weight (none) body weight   [g]  bw_4 QTL population m 4wks N=204
Reifsnyder1 11102 body weight (none) body weight   [g]  bw_8 QTL population m 8wks N=204
Reifsnyder1 11103 body weight (none) body weight   [g]  bw_12 QTL population m 12wks N=204
Reifsnyder1 11104 body weight (none) body weight   [g]  bw_16 QTL population m 16wks N=204
Reifsnyder1 11105 body weight (none) body weight   [g]  bw_20 QTL population m 20wks N=204
Reifsnyder1 11106 body weight (none) body weight   [g]  bw_24 QTL population m 24wks N=204
Reifsnyder1 11107 metabolic panel (none) glucose (plasma)   [mg/dL]  GLU_16 QTL population m 16wks N=204
Reifsnyder1 11108 metabolic panel (none) glucose (plasma), log transformed   [log(mg/dL)]  log_GLU_16 QTL population m 16wks N=204
Reifsnyder1 11109 metabolic panel (none) glucose (plasma)   [mg/dL]  GLU_20 QTL population m 20wks N=204
Reifsnyder1 11110 metabolic panel (none) glucose (plasma), log transformed   [log(mg/dL)]  log_GLU_20 QTL population m 20wks N=204
Reifsnyder1 11111 metabolic panel (none) glucose (plasma)   [mg/dL]  GLU_24 QTL population m 24wks N=204
Reifsnyder1 11112 metabolic panel (none) glucose (plasma), log transformed   [log(mg/dL)]  log_GLU_24 QTL population m 24wks N=204
Reifsnyder1 11113 hormone quantification (none) insulin (plasma)   [ng/mL]  INS_16 QTL population m 16wks N=204
Reifsnyder1 11114 hormone quantification (none) insulin (plasma)   [ng/mL]  INS_20 QTL population m 20wks N=204
Reifsnyder1 11115 hormone quantification (none) insulin (plasma)   [ng/mL]  INS_24 QTL population m 24wks N=204
Reifsnyder1 11116 hormone quantification (none) leptin   [ng/mL]  LEP_24 QTL population m 24wks N=204
Reifsnyder1 11117 fat pad weights (none) inguinal fat pad weight   [g]  inguinal_fat QTL population m 24wks N=204
Reifsnyder1 11118 fat pad weights (none) retroperitoneal fat pad weight at   [g]  peritoneal_fat QTL population m 24wks N=204
Reifsnyder1 11119 fat pad weights (none) mesenteric fat pad weight   [g]  mesenteric_fat QTL population m 24wks N=204
Reifsnyder1 11120 fat pad weights (none) total fat pad weight   [g]  total_fat QTL population m 24wks N=204
Reifsnyder1 11121 fat pad weights (none) percent of body weight that is attributed to fat pads   [%]  pct_fat QTL population m 24wks N=204
Reifsnyder1 11122 body weight (none) body mass index (BMI)   [g/cm2]  BMI QTL population m 24wks N=204
Reifsnyder1 11123 lipid profile (none) plasma triglyceride concentration   [mg/dL]  TG QTL population m 24wks N=204
Reifsnyder1 11124 lipid profile (none) plasma HDL concentration   [mg/dL]  HDLD QTL population m 24wks N=204
Reifsnyder1 11125 lipid profile (none) plasma total cholesterol concentration   [mg/dL]  Chol QTL population m 24wks N=204
To see more rows use the paging control at top.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Dbsty1   Dbsty2   Dbsty3   Dbsty4   Hdlq11   Hdlq15   Hdlq16   Hdlq21   Hdlq48   Hdlq63   Hdlq64   Hdlq68   Hdlq69   Hdlq7   Hdlq71   Hdlq72   Hdlq73   Hdlq74   Hdlq75   Hdlq76   Hdlq77   Tcq3   Tcq4   Tcq5   Tcq6   Tcq7   Tcq8   Tcq9   Tgq30   Tgq31   Tgq32   Tgq33   Tgq34   Tgq4   Tgq5   Tgq6  


Project / data set:   Reifsnyder1     a.k.a. Reifsnyder_2000
Excel file:   Data_Description_NZOxNON_Reifsnyder2000.xlsx
CSV file:   Reifsnyder2000_NZOxNON_B37_Data.csv
Readme / text file:   readme_Reifsnyder2000.txt