Recla1: Diversity Outbred hot plate QTL data (2013)

Recla JM

Recla1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants Jill M Recla       The Jackson Laboratory Bar Harbor, ME
ContactJill M Recla
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported financially by the National Science Foundation IGERT Training Grant, NIH GM076468, and start-up funding from The Jackson Laboratory to EJC. This project was completed by JMR as part of her graduate dissertation research in the Graduate School of Biomedical Sciences (GSBS) at the University of Maine, Orono.
Project type QTL Archive data set
MPD identifiersRecla1     MPD:285
Data changelog No updates/corrections.       Initial release date: 11/2013.
Mouse genetics is a powerful tool for discovering genetic factors influencing human pain sensitivity. However, many previous studies relied on mapping populations that lacked recombinatorial precision, resulting in pain-related quantitative trait loci (QTL) that are quite large, often spanning several megabases and containing numerous candidates. In order to improve genetic mapping efficiency, a cohort of approximately 300 Diversity Outbred mice was tested to identify novel genes associated with acute thermal pain sensitivity. Diversity Outbred mice offer increased genetic heterozygosity, allelic diversity, and recombinatorial precision compared to traditional mouse mapping populations, making them an ideal resource for high-resolution genetic mapping. The candidate pain gene Hydin, encoding axonemal central pair apparatus protein, was identified in a 2.5 Mbp QTL region. The plausibility of Hydin's role in pain response was assessed by combining annotation data from publicly available sources with genetic network analysis tools to visualize known and predicted functional relationships between Hydin and known nervous system genes. Our findings suggest a role for Hydin in pain sensitivity, possibly through the involvement of the cerebrospinal fluid-choroid plexus system.

QTL data set parameters:
Progenitor strains CC8 founder strains    
Cross typeDiversity Outbred
Population size 135 ♀     126 ♂

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Recla1 28501 nociception assay (none) time to respond to heat   [s]  latency_to_respond QTL population both 13-17wks N=131

Project / data set:   Recla1     a.k.a. Recla_2013
Excel file:   Data_Description_DO_Recla2013.xlsx
CSV file:   Recla2013_geno.csv
CSV file:   Recla2013_pheno.csv
Large zipped data set: