Peters5: Hematologic data for F2 progeny of C3H/HeJ+/wan x CAST/EiJ (2004)

Peters LL, Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA. Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency. Blood. 2004 Apr 15;103(8):3233-40. Epub 2003 Dec 30.   PubMed 15070709  


     
Peters5 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants Luanne L Peters       The Jackson Laboratory Bar Harbor, ME
With: Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA
ContactLuanne L Peters     Luanne.Peters@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH HL64885, HL32262, DK34083, RR01183, CA34196; and The March of Dimes
Project type QTL Archive data set
MPD identifiersPeters5     MPD:147
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross between C3H/HeJ+/wan x CAST/EiJ inbred mouse strains was generated to identify QTLs that modify the hereditary spherocytosis (HS) phenotype. RBC count, hematocrit, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin content, were measured in newborn F2 mice with C3H wan mutation (pups die within 72h of birth). For detailed protocols see Peters et al 2004.


QTL data set parameters:
Progenitor strains C3H/HeJ+/wan     CAST/EiJ    
Cross typeF2 intercross
Population size 97 ♀     86 ♂
Agefetuses, newborns


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Peters5 14701 body weight (none) body weight   [g]  bw QTL population both fetuses, newborns N=92
Peters5 14702 complete blood count (none) red blood cell count (RBC) (units per volume x 106)   [n/µL]  RBC QTL population both fetuses, newborns N=92
Peters5 14703 complete blood count (none) hemoglobin (HGB), measured   [g/dL]  mHGB QTL population both fetuses, newborns N=92
Peters5 14704 complete blood count (none) hematocrit (HCT)   [%]  HCT QTL population both fetuses, newborns N=92
Peters5 14705 complete blood count (none) mean corpuscular volume   [fL]  MCV QTL population both fetuses, newborns N=92
Peters5 14706 complete blood count (none) mean of corpuscular hemoglobin concentration   [g/dL]  MCHC QTL population both fetuses, newborns N=92

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Hsm1  


Project / data set:   Peters5     a.k.a. Peters_2004
Excel file:   Data_Description_C3HxCAST_Peters2004.xlsx
CSV file:   Peters2004_C3HxCAST_B37_Data.csv
Readme / text file:   readme_Peters2004.txt
QC plots, figures, etc.:   QCReport_Peters2004.pdf