MPD: Data set: Li1

Li1: Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice (2008)

Li Q, Li Y, Zhang Z, Gilbert TR, Matsumoto AH, Dobrin SE, Shi W. Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Stroke. 2008 Jan;39(1):166-73. Epub 2007 Nov 29. PubMed 18048852 FullText

Li1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Li1 measures:

MA:0000062 aorta
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000181 abnormal circulating LDL cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0001259 abnormal body weight
MP:0005340 altered susceptibility to atherosclerosis
MP:0011969 abnormal circulating triglyceride level
VT:0000180 blood cholesterol amount
VT:0000181 blood LDL cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000272 aorta morphology trait
VT:0001259 body mass
VT:0002644 blood triglyceride amount

Investigators	Q Li Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Li Y, Zhang Z, Gilbert TR, Matsumoto AH, Dobrin SE, Shi W
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	This study was supported by the National Institutes of Health grant HL75433 and by the NHLBI Mammalian Genotyping Service (contract HV48141) for the genotyping.
Project type	QTL Archive data set
MPD identifiers	Li1 MPD:210
Data changelog	No updates/corrections. Initial release date: 08/2010.

Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerotic lesion formation in the carotid arteries on the apolipoprotein E–deficient background when fed Western diet. QTL analysis was performed on an intercross between B6.apoE-/- and C3H.apoE-/- mice to determine genetic factors contributing to variation in the phenotype. The authors found carotid atherosclerosis and plasma lipids are controlled by separate genetic factors in the B6 and C3H mouse model. For detailed protocols see Li et al 2008.

QTL data set parameters:

Progenitor strains	B6.apoE^-/- C3H.apoE^-/-
Cross direction notation	(B6xC3H) F1 x (B6xC3H) F1
Cross type	F2 intercross
Population size	241 ♀ 0 ♂
Age	12wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Li1	lipid profile	western diet	total cholesterol level [mm/dL] Total_cholesterol 21001	QTL population	f	12wks	N=241

Li1	lipid profile	western diet	high-density lipoprotein cholesterol [mm/dL] HDL 21002	QTL population	f	12wks	N=241

Li1	lipid profile	western diet	HDL, log-transformed [log(mm/dL)] LogHDL 21003	QTL population	f	12wks	N=241

Li1	lipid profile	western diet	low-density lipoprotein / very-low-density lipoprotein [mm/dL] LDL/VLDL 21004	QTL population	f	12wks	N=241

Li1	lipid profile	western diet	LDL/VLDL, log transformed [log(mm/dL)] LogLDL/VLDL 21005	QTL population	f	12wks	N=241

Li1	lipid profile	western diet	triglyceride levels [mm/dL] Triglyceride 21006	QTL population	f	12wks	N=241

Li1	body weight	western diet	body weight of mouse Body_weight 21007	QTL population	f	12wks	N=241

Li1	histopathology	western diet	carotid atherosclerotic lesion area size (the average of 5 largest sections) [µm²/section] Carotid_lesion-LGMax 21008	QTL population	f	12wks	N=241

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Cath1 Hdl4 Hdl5 Hdlq15 Hdlq86 Hdlq91 Hdlq94 Lprq4 Nhdlq11 Nhdlq12 Pnhdlc6 Trigq3 Trigq4

Project / data set: Li1 a.k.a. Li_2008
Excel file: Data_Description_C3HxB6_Li2008.xlsx
CSV file: Li2008_C3HxB6_B37_Data.csv
Readme / text file: readme_Li2008.txt
QC plots, figures, etc.: QCReport_Li2008.pdf