Kim1: Genetic analysis of non-insulin-dependent diabetes in backcross progeny between TallyHo and C57BL/6J strains (2001)

Kim JH, Sen S, Avery CS, Simpson E, Chandler P, Nishina PM, Churchill GA, Naggert JK. Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics. 2001 Jun 15;74(3):273-86.   PubMed 11414755  


     
Kim1 downloads
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Participants J H Kim
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Sen S, Avery CS, Simpson E, Chandler P, Nishina PM, Naggert JK
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by National Institutes of Health Grant DK-46977 (J.K.N.) and American Heart Association Postdoctoral Fellowship Award 9820036T (J.H.K.). Institutional shared services were supported by National Cancer Institute Cancer Center Grant CA-34196.
Project type QTL Archive data set
MPD identifiersKim1     MPD:114
Data changelog No updates/corrections.       Initial release date: 09/2011.
The TallyHo (TH) mouse has many diabetes syndromes and this strain is an established model for non-insulin-dependent diabetes mellitus (NIDDM) research. To identify the QTLs linked to hyperglycemia, the male progeny obtained from backcrosses between C57BL/6J and TH, CAST and TH were used to do genetic analysis. This is the backcross data of C57BL/6J and TH strain. A genome-wide scan revealed three QTLs linked to hyperglycemia and one major QTL was mapped to chromosome 19. Additionally, gene–gene interactions contributing to hyperglycemia were also observed from the data analysis. For detailed protocols see Kim et al 2005.


QTL data set parameters:
Progenitor strains C57BL/6J     TALLYHO/JngJ    
Cross direction notation(B6 x TH) x TH
Cross typeBackcross
Population size 0 ♀     206 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Kim1 11401 metabolic panel (none) mean of 3 non-fasted plasma glucose levels measurements   [mg/dL]  Mean_glucose QTL population m 26wks N=206
Kim1 11402 body weight (none) body weight measured at 20 wks   [g]  Body_weight QTL population m 20wks N=206
Kim1 11403 hormone quantification (none) non-fasted insulin level   [ng/mL]  Insulin QTL population m 26wks N=206
Kim1 11404 fat pad weights (none) inguinal fat pad weight   [g]  Inguinal QTL population m 26wks N=206
Kim1 11405 fat pad weights (none) epididymal fat pad weight   [g]  Epididymal QTL population m 26wks N=206
Kim1 11406 fat pad weights (none) mesenteric fat pad weight   [g]  Mesenteric QTL population m 26wks N=206
Kim1 11407 fat pad weights (none) retroperitoneal fat pad weight   [g]  Retroperitoreal QTL population m 26wks N=206
Kim1 11408 fat pad weights (none) subscapular fat pad weight   [g]  Subcutaneous QTL population m 26wks N=206
Kim1 11409 fat pad weights (none) total five fat pad weight   [g]  Total_fat QTL population m 26wks N=206
Kim1 11410 body weight (none) body weight of mouse carcass at week 26   [g]  Carcass_WT QTL population m 26wks N=206
Kim1 11411 fat pad weights (none) sum of five fat pad weights (g)/body weight (g) without the five fat pads   [ratio]  Adiposity_Index QTL population m 26wks N=206
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Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Tabw   Tafat   Tanidd1   Tanidd2   Tanidd3  


Project / data set:   Kim1     a.k.a. Kim_2001
Excel file:   Data_Description_B6xTH_BC_Kim2001.xlsx
CSV file:   Kim2001_B6xTH_BC_B37_Data.csv
Readme / text file:   readme_Kim2001.txt
QC plots, figures, etc.:   QCReport_Kim2001.pdf