Kiernan1: Genetic modifiers affecting ear and eye phenotypes of Jag1 heterozygous mice (2007)

Kiernan AE, Li R, Hawes NL, Churchill GA, Gridley T. Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice. Genetics. 2007 Sep;177(1):307-11.   PubMed 17890364     FullText

Kiernan1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants A E Kiernan
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Li R, Hawes NL, Gridley T
ContactGary A Churchill
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by grants from the National Institutes of Health: NS036437 and DK066387 (to T.G.), DC05865 (to A.E.K.), GM070683 (to G.A.C.), EY07758 (to N.L.H.), and CA034196 (to the Jackson Laboratory).
Project type QTL Archive data set
MPD identifiersKiernan1     MPD:200
Data changelog No updates/corrections.       Initial release date: 10/2009.
Mice heterozygous for a targeted deletion of the Jag1 gene (Jag1del1) were backcrossed to the C3H background to identify genetic modifiers affecting ear and eye phenotypes. For detailed information see Kiernan et al 2007.

QTL data set parameters:
Progenitor strains B6-Jagdel1/+     C3HeB/FeJ    
Cross direction notation(B6xC3H) F1 x C3H
Cross typeN2F1 backcross
Population size 90 ♀     0 ♂
NotesSex not specified, arbitrarily set to female
Agenot specified

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Kiernan1 20001 microscopy (none) status of ampullae (1 = affected, missing; 0 = unaffected, none missing)   [score]  ear QTL population f not specified N=90
Kiernan1 20002 slit lamp (none) status of eye (1 = affected; 0 = unaffected)   [score]  eye QTL population f not specified N=90

Project / data set:   Kiernan1     a.k.a. Kiernan_2007
Excel file:   Data_Description_B6xC3H_Kiernan2007.xlsx
CSV file:   Kiernan2007_B6xC3H_B37_Data.csv
Readme / text file:   readme_Kiernan2007.txt
QC plots, figures, etc.:   QCReport_Kiernan2007.pdf