Karst1: Identification of the genetic determinants for intramuscular fat content and water-holding capacity in high muscle mass mice (2011)

Kärst S, Cheng R, Schmitt AO, Yang H, de Villena FP, Palmer AA, Brockmann GA. Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass. Mamm Genome. 2011 Oct;22(9-10):530-43. Epub 2011 Jul 6.   PubMed 21732194     FullText


     
Karst1 downloads
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Participants B Karst
Abraham Palmer       University of Chicago Chicago, IL
With: Cheng R, Schmitt AO, Yang H, de Villena FP, Brockmann GA
ContactAbraham Palmer     aap@uchicago.edu
AffiliationChurchill Group QTL Archive
AcknowledgementsThis project was supported by the Deutsche Forschungsgemeinschaft (Project BR1285/8-1) and National Institutes of Health grant R21DA024845.
Project type QTL Archive data set
MPD identifiersKarst1     MPD:260
Data changelog No updates/corrections.       Initial release date: 11/2011.
Intramuscular fat content and water-holding capacity are important traits in livestock. To identify genomic regions affecting them, the progeny of two inbred lines of the Berlin Muscle Mouse (BMMI816 and BMMI806), which have high muscle mass, were used as a QTL research model for livestock. These two strains were crossed reciprocally to generate F1, F2, and G3 intercross populations. Multiple related phenotypes have been measured and this is the data of G3 population. The linkage analyses with G3 animals revealed QTL on chromsome 7 and 2. For detailed protocols, see Karst et al 2011.


QTL data set parameters:
Progenitor strains BMMI806     BMMI816    
Cross direction notation(816 x 806) F2 x (816 x 806) F2; (806 x 816) F2 x (806 x 816) F2
Cross typeG3 reciprocal intercross
Population size 160 ♀     172 ♂
NotesG3 progeny


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Karst1 26001 colony observation (none) litter size at day of weaning (day 21) (s ='small' mice; b = 'big' mice )  WG21 QTL population both 3wks N=166
Karst1 26002 colony observation (none) coat color (white = 0, black = 1)  color QTL population both 10wks N=166
Karst1 26003 body weight (none) body weight at day 70   [g]  bwd70 QTL population both 10wks N=166
Karst1 26004 MRI (none) lean mass measured by MRI(1)   [g]  mrilean QTL population both 10wks N=166
Karst1 26005 MRI (none) fat mass measured by MRI   [g]  mrifat QTL population both 10wks N=166
Karst1 26006 organ weights (none) muscle mass, as the sum of 2 Musculus longissimus (ml) + 2 Musculus quadriceps (mq)   [g]  msclemass QTL population both 10wks N=166
Karst1 26007 body weight (none) body weight at day 70, log transformed   [log(g)]  logbwd70 QTL population both 10wks N=166
Karst1 26008 MRI (none) lean mass, log transformed   [log(g)]  logmrilean QTL population both 10wks N=166
Karst1 26009 MRI (none) fat mass, log transformed   [log(g)]  logmrifat QTL population both 10wks N=166
Karst1 26010 organ weights (none) muscle mass, log-transformed   [log(g)]  logmsclemass QTL population both 10wks N=166
Karst1 26011 MRI (none) intramuscular fat content of the M. longissimus   [%]  imfml QTL population both 10wks N=166
Karst1 26012 MRI (none) intramuscular fat content of the M. longissimus, log transformed   [log(%)]  logimfml QTL population both 10wks N=166
Karst1 26013 MRI (none) Intramuscular fat content of the M. quadriceps   [%]  imfmq QTL population both 10wks N=166
Karst1 26014 MRI (none) intramuscular fat content of the M. quadriceps, log transformed   [log(%)]  logimfmq QTL population both 10wks N=166
Karst1 26015 centrifugation (none) Drip Loss in Percent of the M. longissimus   [%]  dipml QTL population both 10wks N=166
Karst1 26016 centrifugation (none) drip loss in percent of the M. longissimus, log transformed   [log(%)]  logdipml QTL population both 10wks N=166
Karst1 26017 centrifugation (none) Drip Loss in Percent of the M. quadriceps   [%]  dipmq QTL population both 10wks N=166
Karst1 26018 centrifugation (none) drip loss in percent of the M. quadriceps, log transformed   [log(%)]  logdipmq QTL population both 10wks N=166
Karst1 26019 metabolic panel (none) fasting blood glucose levels at day 70   [mmol]  gluc70 QTL population both 10wks N=166
Karst1 26020 metabolic panel (none) fasting blood glucose levels at day 70, log transformed   [log(mmol)]  loggluc70 QTL population both 10wks N=166
Karst1 26021 pH assessment (none) pH value of the carcass 1 hour post mortem  ph1 QTL population both 10wks N=166
Karst1 26022 pH assessment (none) pH value of the carcass 1 hour post mortem, log transformed  logph1 QTL population both 10wks N=166
Karst1 26023 pH assessment (none) pH value of the carcass 24 hours post mortem  ph2 QTL population both 10wks N=166
Karst1 26024 pH assessment (none) pH value of the carcass 24 hours post mortem, log transformed  logph2 QTL population both 10wks N=166
Karst1 26025 metabolite quantification (none) glycogen content of the M. longissimus   [mg/g]  glyc QTL population both 10wks N=166
Karst1 26026 metabolite quantification (none) glycogen content of the M. longissimus, log transformed   [log(mg/g)]  logglyc QTL population both 10wks N=166
Karst1 26027 metabolite quantification (none) lactate content of the M. longissimus   [mg/g]  lac QTL population both 10wks N=166
Karst1 26028 metabolite quantification (none) lactate content of the M. longissiumus, log transformed   [log(mg/g)]  loglac QTL population both 10wks N=166
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Project / data set:   Karst1     a.k.a. Karst_2011
Excel file:   Data_Description_BMMI816x806_Karst2011.xlsx
CSV file:   Karst2011_BMMI816x806_B37_Data.csv
Readme / text file:   readme_Karst2011.txt
QC plots, figures, etc.:   QCReport_Karst2011.pdf